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Management of infections in rheumatic patients receiving biological therapies. the Portuguese Society of Rheumatology recommendations

2016Artigo científico Acesso aberto
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dc.contributor.authorTeixeira, Lídia
dc.contributor.authorFonseca, Ana Rita
dc.contributor.authorEugénio, Gisela
dc.contributor.authorRodrigues, Marília
dc.contributor.authorKhmelinskii, Nikita
dc.contributor.authorFernandes, Sílvia
dc.contributor.authorSerra, Sofia
dc.contributor.authorCosta, Tiago
dc.contributor.authorSantos, Maria
dc.date.accessioned2021-12-02T17:39:02Z
dc.date.available2021-12-02T17:39:02Z
dc.date.issued2016
dc.description© Sociedade Portuguesa de Reumatologia |pt_PT
dc.description.abstractIntroduction: Infections are a major cause of morbidity and mortality in systemic inflammatory rheumatic diseases and the management of infectious complications in patients under biological therapies deserves particular attention. Objective: Develop evidence-based recommendations for the management of infections in rheumatic patients receiving biological therapies. Methods: A search in PubMed (until 10 November 2014) and EMBASE (until 20 December 2014) databases was performed. Patients with systemic inflammatory rheumatic diseases treated with approved biologics in whom infections occurred were included. Search results were submitted to title and abstract selection, followed by detailed review of suitable studies. Information regarding presentation of the infectious complication, its diagnosis, treatment, and outcome, as well as maintenance or discontinuation of the biological agent was extracted and subsequently pooled according to the type of infection considered. Results of literature review were presented and critically reviewed in a dedicated meeting by a multidisciplinary panel. Recommendations were then formulated using the Delphi method. Finally, the level of agreement among rheumatologists was voted using an online survey. Results: Fifteen recommendations were issued. Nine general recommendations concerned the assessment of infectious risk before and while on biologics, the procedures in case of suspected infection and the management of biologics during infectious complications. Six specific recommendations were developed for respiratory, urinary, gastrointestinal, skin, osteoarticular and disseminated infections. Conclusion: These fifteen recommendations are intended to help rheumatologists in the management of infections in patients on biological therapy. They integrate an extensive literature review, expert opinion and inputs from Portuguese rheumatologists.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationActa Reumatologica Portuguesa, 41(4), 287–304pt_PT
dc.identifier.eissn2184-8777
dc.identifier.issn0303-464X
dc.identifier.urihttp://hdl.handle.net/10451/50258
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Portuguesa de Reumatologiapt_PT
dc.relation.publisherversionhttp://www.actareumatologica.pt/pt_PT
dc.subjectBiologicspt_PT
dc.subjectInfectionspt_PT
dc.subjectTreatmentpt_PT
dc.subjectRecommendationspt_PT
dc.titleManagement of infections in rheumatic patients receiving biological therapies. the Portuguese Society of Rheumatology recommendationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage304pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage287pt_PT
oaire.citation.titleActa Reumatologica Portuguesapt_PT
oaire.citation.volume41pt_PT
person.familyNameKhmelinskii
person.familyNameSantos
person.givenNameNikita
person.givenNameMaria Jose
person.identifier.ciencia-idA816-90BB-845E
person.identifier.ciencia-id441A-CD98-8FD6
person.identifier.orcid0000-0001-6358-7388
person.identifier.orcid0000-0002-7946-1365
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication20951934-70b7-4bda-ba08-498f9742e462
relation.isAuthorOfPublication288e25e9-3f56-4cab-afff-0cda5478f1ba
relation.isAuthorOfPublication.latestForDiscovery20951934-70b7-4bda-ba08-498f9742e462

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