Publicação
Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation
| dc.contributor.author | Silva, M. F. B. | |
| dc.contributor.author | Aires, C. C. P. | |
| dc.contributor.author | Luis, P. B. M. | |
| dc.contributor.author | Ruiter, J. P. N. | |
| dc.contributor.author | IJist, L. | |
| dc.contributor.author | Duran, M. | |
| dc.contributor.author | Wanders, R. J. A. | |
| dc.contributor.author | de Almeida, I. Tavares | |
| dc.date.accessioned | 2015-12-30T10:18:36Z | |
| dc.date.available | 2015-12-30T10:18:36Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | Valproic acid (VPA; 2-n-propylpentanoic acid) is widely used as a major drug in the treatment of epilepsy and in the control of several types of seizures. Being a simple fatty acid, VPA is a substrate for the fatty acid P-oxidation (FAO) pathway, which takes place primarily in mitochondria. The toxicity of valproate has long been considered to be due primarily to its interference with mitochondrial P-oxidation. The metabolism of the drug, its effects on enzymes of FAO and their cofactors such as CoA and/or carnitine will be reviewed. The cumulative consequences of VPA therapy in inborn errors of metabolism (IEMs) and the importance of recognizing an underlying IEM in cases of VPA-induced steatosis and acute liver toxicity are two different concepts that will be emphasized. | |
| dc.format | application/pdf | |
| dc.identifier.citation | JOURNAL OF INHERITED METABOLIC DISEASE, APR 2008. - p. 205-216 | |
| dc.identifier.doi | http://dx.doi.org/10.1007/s10545-008-0841-x | |
| dc.identifier.isbn | Child Hlth, Great O | |
| dc.identifier.uri | http://hdl.handle.net/10451/21686 | |
| dc.language.iso | eng | |
| dc.publisher | DORDRECHT | |
| dc.subject | Endocrinology & Metabolism | |
| dc.subject | Genetics & Heredity | |
| dc.title | Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation | |
| dc.title | A review | |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 216 | por |
| oaire.citation.startPage | 205 | por |
| rcaap.rights | restrictedAccess | |
| rcaap.type | article |