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Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study

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dc.contributor.authorAdams, David
dc.contributor.authorPolydefkis, Michael
dc.contributor.authorGonzález-Duarte, Alejandra
dc.contributor.authorWixner, Jonas
dc.contributor.authorKristen, Arnt V.
dc.contributor.authorSchmidt, Hartmut H.
dc.contributor.authorBerk, John L.
dc.contributor.authorLosada López, Inés Asunción
dc.contributor.authorDispenzieri, Angela
dc.contributor.authorQuan, Dianna
dc.contributor.authorConceição, Isabel M.
dc.contributor.authorKyriakides, Theodoros
dc.contributor.authorWaucquier, Nawal
dc.contributor.authorCampana-Salort, Emmanuelle
dc.contributor.authorWiesman, Janice
dc.contributor.authorZueiter, Andreas
dc.contributor.authorRezk, Tamer
dc.contributor.authorPerez, Javier M.
dc.contributor.authorCastro, Isabel
dc.contributor.authorCardoso, Marcio
dc.contributor.authorRyder, Julie
dc.contributor.authorThéaudin-Saliou, Marie
dc.contributor.authorZamba-Papanicolaou, Eleni
dc.contributor.authorKraus, Deborah
dc.contributor.authorKim, Byoung-Joon
dc.contributor.authorCorreia, Nuno
dc.contributor.authorMin, Ju-Hong
dc.contributor.authorFranco, Ana
dc.contributor.authorSuhr, Ole
dc.contributor.authorKatanazaka, Kimitaka
dc.contributor.authorTaylor, Mark
dc.contributor.authorHayman, Suzanne R.
dc.contributor.authorAgathangelou, Petros
dc.contributor.authorAldinc, Emre
dc.contributor.authorCoskun, Derya J.
dc.contributor.authorDiallo, Saran
dc.contributor.authorDias da Silva, Moises
dc.contributor.authorSuan, Daniel
dc.contributor.authorDalton, James
dc.contributor.authorYang, Chih-Chao
dc.contributor.authorViera Lima, Ana Flavia
dc.contributor.authorMezei, Michelle M.
dc.contributor.authorBrice, Sylvie
dc.contributor.authorSellers, Peter
dc.contributor.authorAbu-Manneh, Rana
dc.contributor.authorCortese, Andrea
dc.contributor.authorLeonidou, Eleni
dc.contributor.authorStone, Paula
dc.contributor.authorHobbs, Miriam
dc.contributor.authorCauquil-Michon, Cécile
dc.contributor.authorEhinger, Vincent
dc.contributor.authorBalaya-Gouraya, Line
dc.contributor.authorBoyer, Leslie
dc.contributor.authorSeok, Jin Myoung
dc.contributor.authorSignate, Aissatou
dc.contributor.authorKhoshnoodi, Mohammad
dc.contributor.authorCriollo Mora, Elia
dc.contributor.authorJozefowicz, Elsa
dc.contributor.authorWajnsztajn, Fernanda
dc.contributor.authorTaniguchi, Ikuko
dc.contributor.authorEliahou, Ludivine
dc.contributor.authorPouget, Jean
dc.contributor.authorOda, Junko
dc.contributor.authorSoderberg, Karin
dc.contributor.authorLe Corvoisier, Philippe
dc.contributor.authorNienhuis, Hans
dc.contributor.authorChaudhry, Vinay
dc.contributor.authorVictory, Jennifer
dc.contributor.authorYamashita, Taro
dc.contributor.authorRezzan, Kus Jülide
dc.contributor.authorGuerrero Sola, Antonio
dc.contributor.authorLuigetti, Marco
dc.contributor.authorDalia, Samir
dc.contributor.authorAjroud-Driss, Senda Ajroud-Driss
dc.contributor.authorKenepp, Amanda
dc.contributor.authorBournane, Halima
dc.contributor.authorHwa, Lisa
dc.contributor.authorSegawa, Akiko
dc.contributor.authorMartins da Silva, Ana
dc.contributor.authorKapoor, Prashant
dc.contributor.authorLiu, Qingfeng
dc.contributor.authorHokezu, Youichi
dc.contributor.authorGorevic, Peter
dc.contributor.authorPinto, Luiz Felipe
dc.contributor.authorPalacios, Marta
dc.contributor.authorLambrianides, Sakis
dc.contributor.authorBerthelot, Emeline
dc.contributor.authorKaramursel, Sacit
dc.contributor.authorTugal Tutkun, Nuriye Ilknur
dc.contributor.authorKasprzyk, Emmanuelle
dc.contributor.authorElrezzi, Elise
dc.contributor.authorGonzalez, Leidy J.
dc.contributor.authorVerschueren, Annie
dc.contributor.authorSweetser, Marianne T.
dc.contributor.authorGarcía Feijoo, Julián
dc.contributor.authorRosti, Vittorio
dc.contributor.authorLee, Kia
dc.contributor.authorChoi, Kyomin
dc.contributor.authorAnan, Intissar
dc.contributor.authorMihailovic, Natasa
dc.contributor.authorOshita, Tomohiko
dc.contributor.authorRajkumar, Vincent S.
dc.contributor.authorPedrosa-Domellöf, Fatima
dc.contributor.authorHipólito Reis, Antonio
dc.contributor.authorKoujin, Yoko
dc.contributor.authorWalter, Doreen
dc.contributor.authorHosokawa, Yuko
dc.contributor.authorMeguig, Sayah
dc.contributor.authorVista, Geno
dc.contributor.authorLozza, Alessandro
dc.contributor.authorHachulla, Eric
dc.contributor.authorLee, Hye Lim
dc.contributor.authorGauvain, Clement
dc.contributor.authorYeh, Shin-Joe
dc.contributor.authorMartin, Nathalie
dc.contributor.authorDioso, Holly
dc.contributor.authorChu, Hanh
dc.contributor.authorÖzdemir, Betül
dc.contributor.authorFrenzel, Lukas F.
dc.contributor.authorPytel Cordoba, Vanesa
dc.contributor.authorCherneva, Zheyna
dc.contributor.authorChacko, Liza
dc.contributor.authorTran, Leyla
dc.contributor.authorMunoz Beamud, Francisco
dc.contributor.authorAttarian, Shahram
dc.contributor.authorElabed, Mongia
dc.contributor.authorMarques Júnior, Wilson
dc.contributor.authorPester, Lars
dc.contributor.authorGertz, Morie A.
dc.contributor.authorLazzari, Victoria
dc.contributor.authorHein, Selina
dc.contributor.authorOrellana, Lucas G.
dc.contributor.authorStewart, Graeme
dc.contributor.authorSacko, Niamey
dc.contributor.authorPérez-Castañeda, Sandra Lorena
dc.contributor.authorMarques Coutinho, Barbara
dc.contributor.authorCoelho, Teresa
dc.contributor.authorLopate, Glenn
dc.contributor.authorRuiz, Julie
dc.contributor.authorSakurada, Naonori
dc.contributor.authorDo, Thi Hoa (Therese)
dc.contributor.authorGervais de Santa Rosa, Renata
dc.contributor.authorTournev, Ivaylo
dc.contributor.authorSerbest, Nail G.
dc.contributor.authorFreitas, Monica
dc.contributor.authorRodas Marin, Lida Maria
dc.contributor.authorNordh, Erik
dc.contributor.authorDyck, Peter
dc.contributor.authorMazzeo, Anna
dc.contributor.authorLin, Yi
dc.contributor.authorDeLong, Douglas
dc.contributor.authorErnande, Laura
dc.contributor.authorVervoitte, Laetitia
dc.contributor.authorChan, Soo Looi
dc.contributor.authorZibert, Andree
dc.contributor.authorMeng, Ulrike
dc.contributor.authorLee, Ming-Jen
dc.contributor.authorShah, Syed Mahmood
dc.contributor.authorYamanishi, Yuki
dc.contributor.authorMiyazawa, Chinatsu
dc.contributor.authorZhelyazkova-Glaveeva, Sashka
dc.contributor.authorFujita, Akemi
dc.contributor.authorHsieh, Sung-Tsang
dc.contributor.authorGerk, Olga
dc.contributor.authorLee, Ga Yeon
dc.contributor.authorDingli, David
dc.contributor.authorVuong, Thao
dc.contributor.authorRusso, Massimo
dc.contributor.authorHrkman, Nicole
dc.contributor.authorMatsumoto, Kazuhiko
dc.contributor.authorMiller, Sarah
dc.contributor.authorNguyen, David
dc.contributor.authorSmith, Ashley
dc.contributor.authorRigo Oliver, Elena
dc.contributor.authorMoreira, Carolina Lavigne
dc.contributor.authorMartinez-Naharro, Ana
dc.contributor.authorTakahashi, Tetsuya
dc.contributor.authorBerber, Erhan
dc.contributor.authorLow, Soon Chai
dc.contributor.authorKoto, Shusuke
dc.contributor.authorShimomura, Masahiro
dc.contributor.authorItoya, Amenze
dc.contributor.authorUlbricht, Hannah
dc.contributor.authorFerreira, Natalia
dc.contributor.authorGo, Ronald
dc.contributor.authorJarrett, Raquel
dc.contributor.authorCho, Eun Bin
dc.contributor.authorPu, Helen
dc.contributor.authorFlorence, Julaine
dc.contributor.authorAlgalarrondo, Vincent
dc.contributor.authorBernardo, Daniela
dc.contributor.authorLi, Steve
dc.contributor.authorOda, Tetsuya
dc.contributor.authorTaylor, Lenka
dc.contributor.authorVest, John
dc.contributor.authorJehan Lacour, Nathalie
dc.contributor.authorZepeda, Karla A.
dc.contributor.authorRakotondratafika, Fetra
dc.contributor.authorYe, Jing
dc.contributor.authorScheid, Christof
dc.contributor.authorMorino, Hiroyuki
dc.contributor.authorOvercash, J. Scott
dc.contributor.authorLachmann, Helen J.
dc.contributor.authorCampistol, Josep M.
dc.contributor.authorCantú Brito, Carlos Gerardo
dc.contributor.authorWhite, Matthew T.
dc.contributor.authorO'Riordan, William
dc.contributor.authorInamo, Jocelyn
dc.contributor.authorParas, Allan
dc.contributor.authorSarafov, Staiko
dc.contributor.authorLahme, Larissa
dc.contributor.authorCasey, Patricia
dc.contributor.authorHeintzman, Sarah
dc.contributor.authorPinto, Marcus Vinicius
dc.contributor.authorVinas, Maita
dc.contributor.authorStephant, Maeva
dc.contributor.authorGiang, Lien
dc.contributor.authorLin, Kon-Ping
dc.contributor.authorLeung, Nelson
dc.contributor.authorLopes, Ana
dc.contributor.authorBisogni, Giulia
dc.contributor.authorKim, Arreum
dc.contributor.authorObici, Laura
dc.contributor.authorCárdenas-Soto, Karla
dc.contributor.authorFriebel, Frauke
dc.contributor.authorMonte, Julia R.
dc.contributor.authorLitcanov, Debora Cristina
dc.contributor.authorBulthuis-Kuiper, Janita
dc.contributor.authorCohen, Oliver
dc.contributor.authorGamez Martinez, Jose M
dc.contributor.authorFukase, Emi
dc.contributor.authorBrannagan III, Thomas H.
dc.contributor.authorGillmore, Julian D.
dc.contributor.authorDescals, Cristina
dc.contributor.authorDávila, Lucía Galán
dc.contributor.authorCisneros Barroso, Eugenia
dc.contributor.authorTruong, Nghi
dc.contributor.authorUson, Mercedes
dc.contributor.authorGonsalves, Wilson
dc.contributor.authorJose Vega, Francisco
dc.contributor.authorCharlin, Cyril
dc.contributor.authorMoritaka, Taiga
dc.contributor.authorHuesing-Kabar, Anna
dc.contributor.authorMason, Garnette
dc.contributor.authorPereira, Pedro
dc.contributor.authorCastro, Jose
dc.contributor.authorMasuda, Teruaki
dc.contributor.authorSommerville, R. Brian
dc.contributor.authorFiguerola, Antoni
dc.contributor.authorLust, John A
dc.contributor.authorChao, Chi-Chao
dc.contributor.authorMauricio, Elizabeth A.
dc.contributor.authorTard, Celine
dc.contributor.authorHoltick, Udo
dc.contributor.authorRomano, Angela
dc.contributor.authorKim, JuHyeon
dc.contributor.authorCarrillo, Esmeralda
dc.contributor.authoraus dem Siepen, Fabian
dc.contributor.authorLee, Yi-Chung
dc.contributor.authorNot, Adeline
dc.contributor.authorGiardino, Elena
dc.contributor.authorBecquemont, Laurent
dc.contributor.authorKumar, Shaji K.
dc.contributor.authorHernandez Reyes, Jose Pablo
dc.contributor.authorSankey, Alison
dc.contributor.authorJack, Kristin
dc.contributor.authorBarroso, Fabio
dc.contributor.authorLoRusso, Samantha
dc.contributor.authorGaouar, Amina
dc.contributor.authorBaskin, Amber
dc.contributor.authorLamas, Filipa
dc.contributor.authorLautre, Andrea
dc.contributor.authorSchilling, Matthias
dc.contributor.authorRodríguez Rodríguez, Adrián
dc.contributor.authorChamova, Teodora
dc.contributor.authorWang, Jing Jing
dc.contributor.authorPessoa, Bernardete
dc.contributor.authorMisumi, Yohei
dc.contributor.authorGuimaraes, Nadia
dc.contributor.authorUeno, Hiroki
dc.contributor.authorDixon, Stacy
dc.contributor.authorWaters, Michael
dc.contributor.authorLaw, Steven
dc.contributor.authorWeimer, Louis
dc.contributor.authorDeplanque, Dominique
dc.contributor.authorNoe-Schwenn, Simone
dc.contributor.authorDimberg, Elliot
dc.contributor.authorCakar, Arman
dc.contributor.authorRussell, Stephen J.
dc.contributor.authorShin, Hyun Jin
dc.contributor.authorBeaudonnet, Guillemette
dc.contributor.authorHarada, Masaya
dc.contributor.authorBurks, Kathleen L.
dc.contributor.authorDang, Lien
dc.contributor.authorBlume, Brianna
dc.contributor.authorTsang, Steven
dc.contributor.authorOh, Jeeyoung
dc.contributor.authorDelmont, Emilien
dc.contributor.authorNezu, Tomohisa
dc.contributor.authorUeda, Akihiko
dc.contributor.authorWells, Karen
dc.contributor.authorAlves, Cristina
dc.contributor.authorNakahara, Keiichi
dc.contributor.authorYorita, Akiko
dc.contributor.authorAndo, Rina
dc.contributor.authorGonzález Moreno, Juan
dc.contributor.authorDi Paolantonio, Andrea
dc.contributor.authorKishida, Dai
dc.contributor.authorTsuruhisa, Seiko
dc.contributor.authorElitok, Ali
dc.contributor.authorMigaud-Chervy, Maria-Claire
dc.contributor.authorWitzig, Thomas E.
dc.contributor.authorCioroiu, Comana
dc.contributor.authorArrouasse, Raphaele
dc.contributor.authorPerez de Isla, Leopoldo
dc.contributor.authorAllen, Adriane C.
dc.contributor.authorJeon, Eun-Seok
dc.contributor.authorSchubert, Friederike
dc.contributor.authorNakano, Takahiro
dc.contributor.authorFalk, Malin
dc.contributor.authorDaccach Marques, Vanessa
dc.contributor.authorKleyman, Inna
dc.contributor.authorCherninkova-Gopina, Sylvia
dc.contributor.authorTaniwaki, Takayuki
dc.contributor.authorPlanté-Bordeneuve, Violaine
dc.contributor.authorFayerman, Raisy
dc.contributor.authorTada, Satoshi
dc.contributor.authorEndo, Hironobu
dc.contributor.authorMontala, Carles
dc.contributor.authorLebellec, Loic
dc.contributor.authorGuglielmino, Valeria
dc.contributor.authordel Mar Saniger Alba, Maria
dc.contributor.authorSalhi, Hayet
dc.contributor.authorCardoso Berensztejn, Amanda
dc.contributor.authorFalcao de Campos, Catarina
dc.contributor.authorRougeaux, Isabelle
dc.contributor.authorLe, An
dc.contributor.authorAyache, Samar S.
dc.contributor.authorKato, Nagaaki
dc.contributor.authorZwijack, Brittany
dc.contributor.authorGentile, Luca
dc.contributor.authorLindqvist, Per
dc.contributor.authorKuzume, Daisuke
dc.contributor.authorJudge, Daniel P.
dc.contributor.authorSabatelli, Mario
dc.contributor.authorGrapperon, Aude-Marie
dc.contributor.authorUeda, Mitsuharu
dc.contributor.authorFonder, Amie
dc.contributor.authorAl-Salameh, Abdallah
dc.contributor.authorLecoq, Anne-Lise
dc.contributor.authorBlasco Pelicano, Josep Miquel
dc.contributor.authorSirin Inan, Nermin G.
dc.contributor.authorLabeyrie, Celine
dc.contributor.authorGragera Martínez, Álvaro
dc.contributor.authorImai, Akira
dc.contributor.authorBrueckner, Caitlin
dc.contributor.authorSu, Jen-Jen
dc.contributor.authorGilmore, Catherine
dc.contributor.authorMeyrath, David
dc.contributor.authorGendre, Thierry
dc.contributor.authorHineno, Akiyo
dc.contributor.authorChahine, Ilonah
dc.contributor.authorBoubrit, Yasmine
dc.contributor.authorKodaira, Minori
dc.contributor.authorYoshinaga, Tsuneaki
dc.contributor.authorShije, Jeffrey
dc.contributor.authorSlama, Michel S.
dc.contributor.authorSekijima, Yoshiki
dc.contributor.authorRivera de la Parra, David
dc.contributor.authorNagai, Masahiro
dc.contributor.authorNeves, Carlos
dc.contributor.authorMoscardini, Mariana
dc.contributor.authorPark, Jae Hong
dc.contributor.authorHorga, Alejandro
dc.contributor.authorChoumert, Ariane
dc.contributor.authorLim, He Eng Li
dc.contributor.authorValdrez, Katia
dc.contributor.authorMiyahara, Teruyoshi
dc.contributor.authorWade, N. Kevin
dc.contributor.authorKim, Hee Jin
dc.contributor.authorThai, Desmond
dc.contributor.authorde Azevedo Coutinho, Conceição
dc.contributor.authorBauer, Ralf
dc.contributor.authorRamalho, Joana
dc.contributor.authorMay, John
dc.contributor.authorJoslin, Benjamin C.
dc.contributor.authorSantos, Miguel Oliveira
dc.contributor.authorFreimer, Miriam
dc.contributor.authorUlane, Christina
dc.contributor.authorMegelin, Thomas
dc.contributor.authorPedrosa, Salve
dc.contributor.authorPilebro, Bjorn
dc.contributor.authorBorrachero, Cristina
dc.contributor.authorSanz, Monica
dc.contributor.authorOwusu-Sekyere, Mercy
dc.contributor.authorNguyen, Tyler
dc.contributor.authorEchaniz-Laguna, Andoni
dc.contributor.authorAltinkurt, Emre
dc.contributor.authorRodrigues, Leonardo
dc.contributor.authorZeldenrust, Steven R
dc.contributor.authorTsai, Li-Kai
dc.contributor.authorKabar, Iyad
dc.contributor.authorHamaguchi, Hirotoshi
dc.contributor.authorJiménez López, Brenda Poled
dc.contributor.authorGreen, Sinikka
dc.contributor.authorVorona, Elena
dc.contributor.authorWaddington-Cruz, Márcia
dc.contributor.authorMerlini, Giampaolo
dc.contributor.authorDurmus, Hacer
dc.contributor.authorNeshige, Shuichiro
dc.contributor.authorMeyle, Eva
dc.contributor.authorGoh, Khean Jin
dc.contributor.authorSahin, Erdi
dc.contributor.authorKleinschmidt, Natalia
dc.contributor.authorFocseneanu, Cecile
dc.contributor.authorParman, Yesim
dc.contributor.authorRousseau, Antoine
dc.contributor.authorMekhael, Linda
dc.date.accessioned2022-09-07T14:29:35Z
dc.date.available2022-09-07T14:29:35Z
dc.date.issued2021
dc.description© 2020 Elsevier Ltd. All rights reserved.pt_PT
dc.description.abstractBackground: Hereditary transthyretin-mediated amyloidosis is a rare, inherited, progressive disease caused by mutations in the transthyretin (TTR) gene. We assessed the safety and efficacy of long-term treatment with patisiran, an RNA interference therapeutic that inhibits TTR production, in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy. Methods: This multicentre, open-label extension (OLE) trial enrolled patients at 43 hospitals or clinical centres in 19 countries as of Sept 24, 2018. Patients were eligible if they had completed the phase 3 APOLLO or phase 2 OLE parent studies and tolerated the study drug. Eligible patients from APOLLO (patisiran and placebo groups) and the phase 2 OLE (patisiran group) studies enrolled in this global OLE trial and received patisiran 0·3 mg/kg by intravenous infusion every 3 weeks with plans to continue to do so for up to 5 years. Efficacy assessments included measures of polyneuropathy (modified Neuropathy Impairment Score +7 [mNIS+7]), quality of life, autonomic symptoms, nutritional status, disability, ambulation status, motor function, and cardiac stress, with analysis by study groups (APOLLO-placebo, APOLLO-patisiran, phase 2 OLE patisiran) based on allocation in the parent trial. The global OLE is ongoing with no new enrolment, and current findings are based on the interim analysis of the patients who had completed 12-month efficacy assessments as of the data cutoff. Safety analyses included all patients who received one or more dose of patisiran up to the data cutoff. This study is registered with ClinicalTrials.gov, NCT02510261. Findings: Between July 13, 2015, and Aug 21, 2017, of 212 eligible patients, 211 were enrolled: 137 patients from the APOLLO-patisiran group, 49 from the APOLLO-placebo group, and 25 from the phase 2 OLE patisiran group. At the data cutoff on Sept 24, 2018, 126 (92%) of 137 patients from the APOLLO-patisiran group, 38 (78%) of 49 from the APOLLO-placebo group, and 25 (100%) of 25 from the phase 2 OLE patisiran group had completed 12-month assessments. At 12 months, improvements in mNIS+7 with patisiran were sustained from parent study baseline with treatment in the global OLE (APOLLO-patisiran mean change -4·0, 95 % CI -7·7 to -0·3; phase 2 OLE patisiran -4·7, -11·9 to 2·4). Mean mNIS+7 score improved from global OLE enrolment in the APOLLO-placebo group (mean change from global OLE enrolment -1·4, 95% CI -6·2 to 3·5). Overall, 204 (97%) of 211 patients reported adverse events, 82 (39%) reported serious adverse events, and there were 23 (11%) deaths. Serious adverse events were more frequent in the APOLLO-placebo group (28 [57%] of 49) than in the APOLLO-patisiran (48 [35%] of 137) or phase 2 OLE patisiran (six [24%] of 25) groups. The most common treatment-related adverse event was mild or moderate infusion-related reactions. The frequency of deaths in the global OLE was higher in the APOLLO-placebo group (13 [27%] of 49), who had a higher disease burden than the APOLLO-patisiran (ten [7%] of 137) and phase 2 OLE patisiran (0 of 25) groups. Interpretation: In this interim 12-month analysis of the ongoing global OLE study, patisiran appeared to maintain efficacy with an acceptable safety profile in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy. Continued long-term follow-up will be important for the overall assessment of safety and efficacy with patisiran.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLancet Neurol. 2021 Jan;20(1):49-59pt_PT
dc.identifier.doi10.1016/S1474-4422(20)30368-9pt_PT
dc.identifier.eissn1474-4465
dc.identifier.issn1474-4422
dc.identifier.urihttp://hdl.handle.net/10451/54360
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/the-lancet-neurologypt_PT
dc.titleLong-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage59pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage49pt_PT
oaire.citation.titleThe Lancet Neurologypt_PT
oaire.citation.volume20pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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