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Recombinant human erythropoietin protects the liver from hepatic ischemia-reperfusion injury in the rat

2006Artigo científico Apenas metadados
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dc.contributor.authorSepodes, Bruno
dc.contributor.authorMaio, Rui
dc.contributor.authorPinto, Rui
dc.contributor.authorSharples, Edward
dc.contributor.authorOliveira, Pedro
dc.contributor.authorMcDonald, Michelle
dc.contributor.authorYaqoob, Muhammad
dc.contributor.authorThiemermann, Christoph
dc.contributor.authorMota-Filipe, Helder
dc.date.accessioned2015-12-30T10:17:18Z
dc.date.available2015-12-30T10:17:18Z
dc.date.issued2006
dc.description.abstractRecently, erythropoietin was shown to have both hematopoietic as well as tissue-protective properties. Erythropoietin (EPO) had a protective effect in animal models of cerebral ischemia, mechanical trauma of the nervous system, myocardial infarction, and ischemia-reperfusion (I/R) injury of the kidney. It is not known whether EPO protects the liver against I/R injury. Using a rat model of liver I/R injury, we aimed to determine the effect of the administration of human recombinant erythropoietin (rhEPO) on liver injury. Rats were subjected to 30 min of liver ischemia followed by 2 h of reperfusion. When compared with the sham-operated rats, I/R resulted in significant rises in the serum levels of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, gamma-glutamyl transferase, tissue lipid peroxidation, caspase-3 activity and altered histology. Administration of rhEPO 5 min before ischemia was able to reduce the biochemical evidence of liver injury; however, this protection was not evident when rhEPO was administered 5 min before reperfusion. Mechanistically, early administration of rhEPO was able to reduce the oxidative stress and caspase-3 activation, suggesting the subsequent reduction of apoptosis. This study provides the first evidence that rhEPO causes a substantial reduction of the liver injury induced by I/R in the rat.
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dc.identifier.citationTRANSPLANT INTERNATIONAL. - Vol. 19, n. 11 (NOV 2006), p. 919-926
dc.identifier.doihttp://dx.doi.org/10.1111/j.1432-2277.2006.00366.x
dc.identifier.issn0934-0874
dc.identifier.urihttp://hdl.handle.net/10451/21005
dc.language.isoeng
dc.publisherBLACKWELL PUBLISHING
dc.subjectSurgery
dc.subjectTransplantation
dc.titleRecombinant human erythropoietin protects the liver from hepatic ischemia-reperfusion injury in the rat
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage926por
oaire.citation.startPage919por
oaire.citation.titleTRANSPLANT INTERNATIONALpor
oaire.citation.volumeVol. 19por
rcaap.rightsrestrictedAccess
rcaap.typearticle

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