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Atherosclerosis and bone loss in humans: results from deceased donors and from patients submitted to carotid endarterectomy

2021Journal article Open access
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dc.contributor.authorCarmona-Fernandes, Diana
dc.contributor.authorBarreira, Sofia
dc.contributor.authorLeonardo, Natacha
dc.contributor.authorCasimiro, Renata I.
dc.contributor.authorCastro, Alice M.
dc.contributor.authorSantos, Pedro Oliveira
dc.contributor.authorFernandes, António N.
dc.contributor.authorCortes-Figueiredo, Filipe
dc.contributor.authorGonçalves, Carolina A.
dc.contributor.authorCruz, Rafael Moiteiro Da
dc.contributor.authorFernandes, Mariana L.
dc.contributor.authorIvo, Margarida
dc.contributor.authorPedro, Luís M
dc.contributor.authorCanhao, Helena
dc.contributor.authorFonseca, João Eurico
dc.contributor.authorSantos, Maria
dc.date.accessioned2023-06-14T14:24:08Z
dc.date.available2023-06-14T14:24:08Z
dc.date.issued2021
dc.descriptionCopyright © 2021 Carmona-Fernandes, Barreira, Leonardo, Casimiro, Castro, Santos, Fernandes, Cortes-Figueiredo, Gonçalves, Cruz, Fernandes, Ivo, Pedro, Canhão, Fonseca and Santos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractBackground and Aims: Atherosclerosis and osteoporosis share common risk factors, as well as inflammatory mechanisms. Our aim was to understand how atherosclerotic lesions are related with disturbances in bone. Methods: Gene expression of pro-inflammatory and bone metabolism related proteins (IL-1β, IL-6, IL-17A, TNF, RANKL, OPG, COL1, CTSK, OCL, TRAP, CBFA1, DKK1, SOST, ADIPOQ, and ADIPOR1) were analyzed in arteries and bones from 45 deceased donors and adipose tissue was used as control. Additionally, in 139 patients with advanced atherosclerosis submitted to carotid endarterectomy we compared calcium content (Alizarin red) and plaque inflammatory scores (CD3+, CD68+, and adiponectin) of patients with normal bone mineral density (BMD) with those with low BMD and explored the associations between gene expression in atherosclerotic plaques and BMD. Serum levels of pro-inflammatory and bone related proteins were measured both in donors and patients. Associations were investigated by the Pearson or Spearman correlation tests, and multivariate regression analyzes were performed when justified. Results: Gene expression of bone remodeling and pro-inflammatory proteins correlated positively in bone and aorta, independently of age and sex of donors, but not in adipose tissue. The expression of bone formation genes was significantly higher in atheroma plaques from endarterectomized patients with normal vs. low BMD as well as inflammatory CD68+ scores, regardless of patients' age and sex, but not of body mass index. No relationship was observed between serum levels and gene expression levels of pro-inflammatory or bone remodeling proteins. Conclusions: Our results suggest that the relationship between bones and vessels in the context of atherosclerotic disease and osteoporosis may rely on the intrinsic connection between the tissues involved, independently of disease stage. Serum measurements of pro-inflammatory and bone-remodeling proteins do not accurately translate tissue pathologic processes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Med (Lausanne). 2021 May 20;8:672496pt_PT
dc.identifier.doi10.3389/fmed.2021.672496pt_PT
dc.identifier.eissn2296-858X
dc.identifier.urihttp://hdl.handle.net/10451/58208
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/journals/medicinept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAtherosclerosispt_PT
dc.subjectBone remodeling biomarkerspt_PT
dc.subjectOsteoporosispt_PT
dc.subjectPro-inflammatory cytokinespt_PT
dc.subjectTissue expression analysispt_PT
dc.titleAtherosclerosis and bone loss in humans: results from deceased donors and from patients submitted to carotid endarterectomypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Medicinept_PT
oaire.citation.volume8pt_PT
person.familyNameCarmona-Fernandes
person.familyNameBarreira
person.familyNamePereira dos Reis Cortes Figueiredo
person.familyNameMoiteiro da Cruz
person.familyNamePedro
person.familyNameCanhao
person.familyNameFonseca
person.familyNameSantos
person.givenNameDiana
person.givenNameSofia
person.givenNameFilipe Carlos
person.givenNameRafael
person.givenNameLuís
person.givenNameHelena
person.givenNameJoão
person.givenNameMaria Jose
person.identifier668093
person.identifier.ciencia-idA215-421D-FF23
person.identifier.ciencia-id2417-2F03-44CD
person.identifier.ciencia-idD010-B998-18AC
person.identifier.ciencia-idB817-6036-0A77
person.identifier.ciencia-id0B14-1812-24DC
person.identifier.ciencia-idF310-B85D-57C7
person.identifier.ciencia-id441A-CD98-8FD6
person.identifier.orcid0000-0002-1015-3946
person.identifier.orcid0000-0002-6807-559X
person.identifier.orcid0000-0002-3946-3868
person.identifier.orcid0000-0002-0930-2502
person.identifier.orcid0000-0003-4310-9324
person.identifier.orcid0000-0002-3239-2809
person.identifier.orcid0000-0003-1432-3671
person.identifier.orcid0000-0002-7946-1365
person.identifier.ridD-5916-2011
person.identifier.scopus-author-id7004454630
person.identifier.scopus-author-id6602393492
person.identifier.scopus-author-id7101983519
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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