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First description of colistin and tigecycline-resistant acinetobacter baumannii producing KPC-3 carbapenemase in Portugal

2018-11-06Artigo científico Acesso aberto
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dc.contributor.authorCaneiras, Catia
dc.contributor.authorCalisto, Filipa
dc.contributor.authorSilva, Gabriela Jorge da
dc.contributor.authorLito, Luis
dc.contributor.authorCristino, José Melo
dc.contributor.authorDuarte, Aida
dc.date.accessioned2018-11-16T17:15:30Z
dc.date.available2018-11-16T17:15:30Z
dc.date.issued2018-11-06
dc.description© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractHerein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAntibiotics 2018, 7(4), 96pt_PT
dc.identifier.doi10.3390/antibiotics7040096pt_PT
dc.identifier.issn2079-6382
dc.identifier.urihttp://hdl.handle.net/10451/35365
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/journal/antibioticspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntimicrobial resistancept_PT
dc.subjectGram-negative bacteriapt_PT
dc.subjectK. pneumoniaept_PT
dc.subjectA. baumanniipt_PT
dc.subjectKPC-3 carbapenemasept_PT
dc.subjectColistinpt_PT
dc.subjectTigecyclinept_PT
dc.titleFirst description of colistin and tigecycline-resistant acinetobacter baumannii producing KPC-3 carbapenemase in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.titleAntibioticspt_PT
oaire.citation.volume7pt_PT
person.familyNameCaneiras
person.familyNameCalisto
person.familyNameMelo Cristino
person.familyNameDuarte
person.givenNameCatia
person.givenNameFilipa
person.givenNameJosé
person.givenNameAida
person.identifier2524696
person.identifier.ciencia-id5217-449F-3B4F
person.identifier.ciencia-idA019-37CE-102C
person.identifier.ciencia-id871E-6AD6-F37C
person.identifier.ciencia-idD517-F4DB-17C1
person.identifier.orcid0000-0002-3735-8554
person.identifier.orcid0000-0001-5092-2247
person.identifier.orcid0000-0001-8643-1722
person.identifier.orcid0000-0002-0616-4650
person.identifier.ridH-3726-2013
person.identifier.ridM-5272-2013
person.identifier.scopus-author-id55565708000
person.identifier.scopus-author-id7004053640
person.identifier.scopus-author-id35495748300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67e72892-1980-4138-aeeb-244c4222d335
relation.isAuthorOfPublication1701ea54-80a8-4c15-92ed-86c1dcd450e6
relation.isAuthorOfPublicationacefbfd7-46d0-4429-80b1-ad159fe4ca95
relation.isAuthorOfPublicationf7620f51-a5ef-4e71-9cf5-3f34eb294a9d
relation.isAuthorOfPublication.latestForDiscovery67e72892-1980-4138-aeeb-244c4222d335

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