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Assessment reliability and treatment of depression
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Depression is a global problem, which causes significant distress, heavy economic burden, and is potentially lethal. The amount of research articles that try to understand causes of depression and investigate potential cures, have been growing over the last few decades. To ensure the validity of depression research, it is important to use valid measurements of depression. In this work, we examine two measures of depression - the Child Behavior Checklist (CBCL) and a depression-related subset of scales of the Hierarchical Taxonomy of Psychopathology (HiTOP). We find both scales to be valid in their corresponding samples. Finally, we look into oxytocin, a neuropeptide that has shown potential as a treatment of depression in combination with antidepressants and/or cognitive behavior therapy. We look at the longevity of the effect of oxytocin on human brain, as measured by electroencephalography (EEG), and the nature of this effect. Our findings can inform the design of future experiments that use oxytocin in human research.
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Depression HiTOP CBCL Oxytocin EEG Depressão Ocitocina