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Factores de risco cardiovascular : componentes hemorreológicos e hemostasiológicos [12]
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Autores
Orientador(es)
Resumo(s)
A origem e objectivos primordiais do Projecto
Framingham são analisados a par com o
conceito de factor de risco cardiovascular. São referidos os factores de risco tradicionais (dislipidemia, hipertensão arterial, tabagismo, diabetes e intolerância à glicose, idade, sexo masculino, antecedentes familiares de doença
cardiovascular, obesidade) e indicados outros
factores predisponentes e biomarcadores (em
circulação, físicos, morfológicos e genómicos) de doença cardiovascular. Deste conjunto é realçada a importância de alguns factores hemorreológicos e hemostasiológicos como predizentes e ou indicadores da doença
aterosclerótica e eventos cardiovasculares
resultantes.
As dificuldades ainda verificadas na definição do risco cardiovascular resultam da aglutinação sob a mesma designação, de diferentes anomalias, de metodologias sugeridas no mesmo estudo, e das diferentes repercussões que uma dada situação pode ter nos sectores vasculares diferentes. Adicionalmente diferentes factores de risco ou biomarcadores representam aspectos singulares, enquanto outros identificam agregados de indicadores, de vias fisiopatológicas ou etiológicas. A futura
identificação genómica e ou proteómica dos
mecanismos de doença cardiovascular
contribuirá decerto para o esclarecimento da
situação.
The original objectives of the Framingham Project are presented along with the concept of cardiovascular risk factors. The traditional risk factors (dyslipidemia, hypertension, smoking, diabetes/glucose intolerance, age, male gender, family history, and obesity) are discussed together with other predisposing factors and biomarkers of cardiovascular disease (circulating in the blood, physical, morphologic and genomic). Of these, certain hemorheologic and hemostatic factors are highlighted as predictors and/or markers of atherosclerosis and subsequent cardiovascular events. The difficulties encountered in defining cardiovascular risks are the result of different abnormalities being given the same name, different methodologies being used for the same problem, and the different effects that a given condition may have on different vascular sectors. Additionally, some risk factors or biomarkers represent single problems, whereas others identify aggregations of indicators, pathophysiologic pathways or etiologies. In the future, genomic and/or proteomic identification of cardiovascular disease mechanisms may help to clarify the situation.
The original objectives of the Framingham Project are presented along with the concept of cardiovascular risk factors. The traditional risk factors (dyslipidemia, hypertension, smoking, diabetes/glucose intolerance, age, male gender, family history, and obesity) are discussed together with other predisposing factors and biomarkers of cardiovascular disease (circulating in the blood, physical, morphologic and genomic). Of these, certain hemorheologic and hemostatic factors are highlighted as predictors and/or markers of atherosclerosis and subsequent cardiovascular events. The difficulties encountered in defining cardiovascular risks are the result of different abnormalities being given the same name, different methodologies being used for the same problem, and the different effects that a given condition may have on different vascular sectors. Additionally, some risk factors or biomarkers represent single problems, whereas others identify aggregations of indicators, pathophysiologic pathways or etiologies. In the future, genomic and/or proteomic identification of cardiovascular disease mechanisms may help to clarify the situation.
Descrição
Copyright © 2007 Sociedade Portuguesa de Cardiologia. All rights reserved
Palavras-chave
Biomarkers Cardiovascular disease Hemorheology Risk factors
Contexto Educativo
Citação
Rev Port Cardiol 2007; 26 (2):161-182
Editora
Elsevier España