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Non-invasive Pneumococcal pneumonia in Portugal : serotype distribution and antimicrobial resistance

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dc.contributor.authorHorácio, Andreia
dc.contributor.authorLopes, Joana P.
dc.contributor.authorRamirez, Mário
dc.contributor.authorMelo Cristino, José
dc.date.accessioned2021-07-22T15:09:55Z
dc.date.available2021-07-22T15:09:55Z
dc.date.issued2014
dc.descriptionCopyright: © 2014 Horácio et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.pt_PT
dc.description.abstractThere is limited information on the serotypes causing non-invasive pneumococcal pneumonia (NIPP). Our aim was to characterize pneumococci causing NIPP in adults to determine recent changes in serotype prevalence, the potential coverage of pneumococcal vaccines and changes in antimicrobial resistance. Serotypes and antimicrobial susceptibility profiles of a sample of 1300 isolates recovered from adult patients (≥18 yrs) between 1999 and 2011 (13 years) were determined. Serotype 3 was the most frequent cause of NIPP accounting for 18% of the isolates. The other most common serotypes were 11A (7%), 19F (7%), 19A (5%), 14 (4%), 22F (4%), 23F (4%) and 9N (4%). Between 1999 and 2011, there were significant changes in the proportion of isolates expressing vaccine serotypes, with a steady decline of the serotypes included in the 7-valent conjugate vaccine from 31% (1999-2003) to 11% (2011) (P<0.001). Taking together the most recent study years (2009-2011), the potential coverage of the 13-valent conjugate vaccine was 44% and of the 23-valent polysaccharide vaccine was 66%. While erythromycin resistance increased from 8% in 1999-2003 to 18% in 2011 (P<0.001), no significant trend was identified for penicillin non-susceptibility, which had an average value of 18.5%. The serotype distribution found in this study for NIPP was very different from the one previously described for IPD, with only two serotypes in common to the ones responsible for half of each presentation in 2009-2011 - serotypes 3 and 19A. In spite of these differences, the overall prevalence of resistant isolates was similar in NIPP and in IPD.pt_PT
dc.description.sponsorshipA.N. Horácio was supported by grant SFRH/BD/81205/2011, from Fundação para a Ciência e Tecnologia, Portugal. This work was partially supported by Fundação para a Ciência e Tecnologia, Portugal (PTDC/DTP-EPI/1759/2012) and unrestricted research grants from Pfizer and GlaxoSmithKline.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPLoS One. 2014 Jul 30;9(7):e103092.pt_PT
dc.identifier.doi10.1371/journal.pone.0103092pt_PT
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10451/49060
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationCHANGING PNEUMOCOCCAL POPULATION IN ADULTS AS A CONSEQUENCE OF DIFFERENT VACCINATION STRATEGIES
dc.relationBesieged by conjugate vaccination: changes in the pneumococcal population and their genomic consequences
dc.relation.publisherversionhttps://journals.plos.org/plosone/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleNon-invasive Pneumococcal pneumonia in Portugal : serotype distribution and antimicrobial resistancept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/BD/81205/2011
oaire.awardNumberPTDC/DTP-EPI/1759/2012
oaire.awardTitleCHANGING PNEUMOCOCCAL POPULATION IN ADULTS AS A CONSEQUENCE OF DIFFERENT VACCINATION STRATEGIES
oaire.awardTitleBesieged by conjugate vaccination: changes in the pneumococcal population and their genomic consequences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F81205%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-EPI%2F1759%2F2012/PT
oaire.citation.issue7pt_PT
oaire.citation.titlePLoS ONEpt_PT
oaire.citation.volume9pt_PT
oaire.fundingStreamOE
oaire.fundingStream3599-PPCDT
person.familyNameRamos de Almeida Ramirez
person.familyNameMelo Cristino
person.givenNameMário Nuno
person.givenNameJosé
person.identifierB-4993-2008
person.identifier.ciencia-id9C1C-F2A2-4226
person.identifier.ciencia-id871E-6AD6-F37C
person.identifier.orcid0000-0002-4084-6233
person.identifier.orcid0000-0001-8643-1722
person.identifier.ridH-3726-2013
person.identifier.scopus-author-id7201568476
person.identifier.scopus-author-id7004053640
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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