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New antivirals against herpes virus and HIV
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In recent years, the demand for new antiviral compounds has increased markdly. There are many contributing factors to this increased demand, including the ever-increasing prevalence of chronic viral injections such as HIV and heRpes viruses and it is important to inactivate these viruses, because the viral strains are resislant to drugs employed in the treatment of infections. In our Iaboratory, we have studied many types of new compounds as antivirals agents from plants used in African traditional medicine, plants of lhe Portuguese flora and synthesis of new severa types of compounds. In this moment, the antiviral research has been done with new synthesized porphyrin derivatives that are photosensilizers useful to photodynamic therapy. In addilion, catechois from abietic acid were prepared and evaluated for antiviral activity. Their properties were compared with those of carnosic acid, a natural-occurring catechol possessing an abietane skeleton and known as a potent antioxidant with anticancer and antiviral properties.
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Pandalai SG, editor. Recent research developments in infection & immunity. Kerala: Transworld Research Network; 2005. p. 1-10