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Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages
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Resumo(s)
ABSTRACT - Staphylococcus aureus is a relevant agent of skin and soft tissue infections (SSTIs) in animals.
Fifty-five S. aureus comprising all SSTI-related isolates in companion animals, collected between
1999 and 2018 (Lab 1) or 2017 and 2018 (Lab 2), were characterized regarding susceptibility to
antibiotics and heavy metals and carriage of antimicrobial resistance determinants. Clonal lineages
were established by PFGE, MLST and agr typing. Over half of the isolates (56.4%, 31/55) were
methicillin-resistant S. aureus (MRSA), and 14.5% showed a multidrug resistance (MDR) phenotype.
Resistance was most frequently observed for beta-lactams (81.8%, related to blaZ and/or mecA),
fluoroquinolones (56.4%) and macrolides/lincosamides (14.5%, related to erm(A) or erm(C)). The
distributions of heavy-metal MICs allowed the detection of non-wild-type populations associated
with several resistance genes. The collection showed genetic diversity, with prevalence of clonal
lineage ST22-agrI (45.5%, 25/55), comprising only MRSA isolates, and several less frequently detected
clones, including ST5-agrII (14.6%, 8/55), ST398-agrI (9.1%, 5/55) and ST72-agrI (7.3%, 4/55). This
work highlights the high frequency of SSTI-related MRSA strains that reflect the clonal lineages
circulating both in companion animals and humans in Portugal, reinforcing the need for a One Health
approach when studying staphylococci causing infections in companion animals.
Descrição
Research Areas: Infectious Diseases ; Pharmacology & Pharmacy
Palavras-chave
Staphylococcus aureus MRSA Companion animals Antimicrobial resistance Heavy metals Clonal lineages One Health
Contexto Educativo
Citação
Costa SS, Ribeiro R, Serrano M, Oliveira K, Ferreira C, Leal M, Pomba C, Couto I. 2022. Staphylococcus aureus Causing Skin and Soft Tissue Infections in Companion Animals: Antimicrobial Resistance Profiles and Clonal Lineages. Antibiotics, 11(5):599. DOI: https://doi.org/10.3390/ antibiotics11050599
Editora
MDPI