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Gene expression association study in feline mammary carcinomas

2019-08-28Artigo científico Acesso aberto
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dc.contributor.authorFerreira, Daniela
dc.contributor.authorMartins, Bárbara
dc.contributor.authorSoares, Maria
dc.contributor.authorCorreia, Jorge
dc.contributor.authorAdega, Filomena
dc.contributor.authorFerreira, Fernando
dc.contributor.authorChaves, Raquel
dc.date.accessioned2021-09-19T23:14:20Z
dc.date.available2021-09-19T23:14:20Z
dc.date.issued2019-08-28
dc.description.abstractWorks on cancer-related genes expression using feline mammary carcinomas (FMCs) are scarce but crucial, not only to validate these tumours as models for human breast cancer studies but also to improve small animal practice. Here, the expression of the cancer-related genes TP53, CCND1, FUS, YBX1, PTBP1, c-MYC and PKM2 was evaluated by real-time RT-qPCR, in a population of FMCs clinically characterized and compared with the disease-free tissue of the same individual. In most of the FMCs analysed, RNA quantification revealed normal expression levels for TP53, c-MYC, YBX1 and FUS, but overexpression in the genes CCND1, PTBP1 and PKM2. The expression levels of these cancer-related genes are strongly correlated with each other, with exception of c-MYC and PKM2 genes. The integration of clinicopathological data with the transcriptional levels revealed several associations. The oral contraceptive administration showed to be positively related with the TP53, YBX1, CCND1, FUS and PTBP1 RNA levels. Positive associations were found between tumour size and YBX1 RNA, and lymph node metastasis with c-MYC RNA levels. This work allowed to verify that many of these cancer-related genes are associated but may also, indirectly, influence other genes, creating a complex molecular cancer network that in the future can provide new cancer biomarkers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreira D, Martins B, Soares M, Correia J, Adega F, Ferreira F, Chaves R 2019. Gene expression association study in feline mammary carcinomas. PLoS ONE 14(8):e0221776. https://doi.org/10.1371/journal.pone.0221776pt_PT
dc.identifier.doi10.1371/journal.pone.0221776pt_PT
dc.identifier.eissn1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.5/21866
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherYves St-Pierre, Institut national de la recherche scientifique, CANADApt_PT
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221776pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectGene
dc.subjectFeline mammary carcinomas
dc.titleGene expression association study in feline mammary carcinomaspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/142267/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/154629/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F70720%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/154697/PT
oaire.citation.conferencePlaceCanadápt_PT
oaire.citation.issuee0221776pt_PT
oaire.citation.titlePLoS ONEpt_PT
oaire.citation.volumeVol. 14, n.º 8pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFerreira
person.givenNameFernando António da Costa
person.identifier.ciencia-idF81F-D7D4-57C5
person.identifier.orcid0000-0001-5765-576X
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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