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Relevance of feline interferon omega for clinical improvement and reduction of concurrent viral excretion in retrovirus infected cats from a rescue shelter

2013-06Journal article Open access
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dc.contributor.authorGil, Solange
dc.contributor.authorLeal, Rodolfo O.
dc.contributor.authorDuarte, Ana
dc.contributor.authorMcGahie, David
dc.contributor.authorSepúlveda, Nuno
dc.contributor.authorSiborro, Inês
dc.contributor.authorCravo, Joana
dc.contributor.authorCartaxeiro, Clara
dc.contributor.authorTavares, Luís M.
dc.date.accessioned2014-09-25T15:52:45Z
dc.date.available2014-09-25T15:52:45Z
dc.date.issued2013-06
dc.descriptionArticles in International Journalspor
dc.description.abstractFeline Immnunodeficiency (FIV) and Feline Leukemia (FeLV) viruses are common infectious agents in stray cats and shelter environments. Recombinant feline interferon-x (rFeIFNx) has shown an antiviral action not only against FIV and FeLV but also against herpesvirus (FHV-1) and calicivirus (FCV). Sixteen naturally infected FIV/FeLV cats were followed during rFeIFNx therapy in order to monitor clinical signs and to correlate with excretion of concomitant viruses (FCV, FHV-1, feline coronavirus (FCoV) and parvovirus (FPV)). Cats were submitted to clinical evaluations and concomitant virus excretion assessement. Comparing D0–D65, 10/16 cats improved clinical scores. Of the 10 cats positive for FHV-1 on D0, 4 were negative and 6 reduced viral loads. Of the 11 FCoV positive cats, 9 reduced viral loads. The 13 FCV positive cats and the FPV positive cat were negative on D65. In conclusion, rFeIFNx improves clinical signs and reduces concurrent viral excretion in naturally infected retroviral cats.por
dc.identifier.citationGil, S., et al. (2013). Relevance of feline interferon omega for clinical improvement and reduction of concurrent viral excretion in retrovirus infected cats from a rescue shelter. Research in Veterinary Science 94(3), 753–763. doi: 10.1016/j.rvsc.2012.09.025por
dc.identifier.doi10.1016/j.rvsc.2012.09.025
dc.identifier.issn0034-5288
dc.identifier.urihttp://hdl.handle.net/10400.5/7210
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevier Ltd.por
dc.subjectFeline immunodeficiency viruspor
dc.subjectFeline Leukemia Viruspor
dc.subjectInterferonpor
dc.subjectTherapypor
dc.subjectShelterpor
dc.subjectFeline herpesviruspor
dc.subjectFeline coronaviruspor
dc.subjectFeline caliciviruspor
dc.titleRelevance of feline interferon omega for clinical improvement and reduction of concurrent viral excretion in retrovirus infected cats from a rescue shelterpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage763por
oaire.citation.startPage753por
oaire.citation.titleResearch in Veterinary Sciencepor
oaire.citation.volumeVol. 94(3)por
rcaap.rightsopenAccess
rcaap.typearticlepor

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