Logo do repositório
 
Publicação

Depression with melancholic features is associated with higher long-term risk for dementia

2016-09-15Artigo científico Acesso restrito
Ver registo simples
dc.contributor.authorSimões Do Couto, Frederico
dc.contributor.authorLunet, Nuno
dc.contributor.authorGinó, Sandra
dc.contributor.authorChester, Catarina
dc.contributor.authorFreitas, Vanda
dc.contributor.authorMaruta, Carolina
dc.contributor.authorFigueira, Maria Luísa
dc.contributor.authorDe Mendonça, Alexandre
dc.date.accessioned2021-06-24T16:44:45Z
dc.date.available2021-06-24T16:44:45Z
dc.date.issued2016-09-15
dc.descriptionCopyright © 2016 Elsevier B.V. All rights reserved.pt_PT
dc.description.abstractBackground: Depression has been reported to increase the risk of subsequently developing dementia, but the nature of this relation remains to be elucidated. Depression can be a prodrome/manifestation of dementia or an early risk factor, and the effect may differ according to depression subtypes. Our aim was to study the association between early-onset depression and different depression subtypes, and the later occurrence of dementia. Methods: We conducted a cohort study including 322 subjects with depression, recruited between 1977 and 1984. A comparison cohort (non-exposed) was recruited retrospectively, to include 322 subjects admitted at the same hospital for routine surgery (appendicectomy or cholecystectomy), at the same period as the depressed cohort. Subjects were contacted again between 2009 and 2014, to assess their dementia status. We computed the risk for dementia in subjects with early onset depression and quantified the association between different depression subtypes (namely melancholic, anxious, and psychotic) and dementia. Results: The odds of dementia were increased by 2.90 times (95% C.I. 1.61-5.21; p<0.0001) for the depressed cohort when compared to the surgical cohort. When the analysis was restricted to patients younger than 45 years old at baseline, the odds for dementia in the depressed cohort were also significantly higher when compared to the surgical cohort (8.53; 95% C.I. 2.40-30.16). In the multivariate Cox analysis, subjects having depression with melancholic features had an increased risk for developing dementia compared to those without melancholic features (HR=3.64; 95% C.I. 1.78-11.26; p=0.025). Limitations: About 59% of the participants with depression and 53% of those non-exposed were lost during follow up. The inclusion of biological biomarkers would strengthen the results. The sample included a low number of bipolar patients. Conclusions: These results support depression as an early risk factor for dementia. Depression with melancholic features was found as an important risk factor for dementia, playing a main role in the relation between these disorders.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Affect Disord. 2016 Sep 15;202:220-229pt_PT
dc.identifier.doi10.1016/j.jad.2016.05.026pt_PT
dc.identifier.eissn1573-2517
dc.identifier.issn0165-0327
dc.identifier.urihttp://hdl.handle.net/10451/48738
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/journal-of-affective-disorderspt_PT
dc.subjectDementiapt_PT
dc.subjectDepressionpt_PT
dc.subjectHypothalamus-Hypophysis-adrenal axispt_PT
dc.subjectMelancholiapt_PT
dc.subjectRisk factorpt_PT
dc.titleDepression with melancholic features is associated with higher long-term risk for dementiapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage228pt_PT
oaire.citation.startPage220pt_PT
oaire.citation.titleJournal of Affective Disorderspt_PT
oaire.citation.volume202pt_PT
person.familyNameSimões do Couto
person.familyNameMaruta
person.familyNameFigueira
person.familyNamede Mendonça
person.givenNameFrederico
person.givenNameCarolina
person.givenNameMaria Luisa
person.givenNameAlexandre
person.identifier.ciencia-idD117-0296-8086
person.identifier.ciencia-id4B1D-5F59-6221
person.identifier.ciencia-id4018-A916-81EC
person.identifier.ciencia-id1615-41B4-0848
person.identifier.orcid0000-0002-3916-2598
person.identifier.orcid0000-0003-3359-379X
person.identifier.orcid0000-0002-7921-5375
person.identifier.orcid0000-0002-0488-1453
person.identifier.ridJ-9374-2017
person.identifier.scopus-author-id14621494400
person.identifier.scopus-author-id35327513800
person.identifier.scopus-author-id7003320823
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication88e58e2b-630a-44ef-a9c8-15a4c2f74fa7
relation.isAuthorOfPublication4a8bdaf9-480a-4836-ac4b-c80c3b4e0391
relation.isAuthorOfPublicationdd3c81c3-e160-4582-ba61-0c7d9548cf43
relation.isAuthorOfPublication53ca3547-99ce-4b68-9330-7879a54c47b7
relation.isAuthorOfPublication.latestForDiscovery88e58e2b-630a-44ef-a9c8-15a4c2f74fa7

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
Depression_melancholic.pdf
Tamanho:
476.24 KB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

IMM - Artigos em Revistas Internacionais
FM - Artigos em Revistas Internacionais