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Equine endometrosis pathological features: are they dependent on NF-κB signaling pathway?
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Orientador(es)
Resumo(s)
Endometrosis is an important mares’ disease which considerably decreases their fertility.
As classic endometrial classification methods might be insufficient for tissue pathological evaluation,
further categorization into active/inactive and destructive/non-destructive types was developed
by Hoffmann and others. This study aimed to compare NF-κB pathway genes transcription among
histopathological types of endometrosis, following Hoffmann and co-authors’ classification. Endometrial samples, collected postmortem from cyclic mares (n = 100) in estrus or diestrus, were
classified histologically and used for gene transcription assessment. Gene transcription of NF-κB subunits (RelA, NF-κB1, NF-κB2), pro-inflammatory molecules (MCP-1, IL-6), and hyaluronan synthases
(HAS 1, HAS 2, HAS 3) was compared among endometrosis types (active, non-active, destructive,
non-destructive). Most individual mRNA samples showed high expression of RelA, NF-κB1, and
MCP-1 gene transcripts and the destructive type of endometrosis, simultaneously. The expression of
RelA and NF-κB1 genes was higher in active destructive group than in the other groups only in the
follicular phase, as well as being higher in the inactive destructive group than in the others, only in
the mid-luteal phase. The increase in gene transcription of the NF-κB canonical activation pathway
in destructive endometrosis may suggest the highest changes in extracellular matrix deposition.
Moreover, the estrous cycle phase might influence fibrosis pathogenesis.
Descrição
Research Areas: Agriculture ; Veterinary Sciences ; Zoology
Palavras-chave
Endometrosis Mare NF-κB MCP-1 IL-6 HAS
Contexto Educativo
Citação
Jasinski T, Zdrojkowski L, Kautz E, Juszczuk-Kubiak E, Ferreira-Dias G, Domino M. 2021. Equine endometrosis pathological features: are they dependent on NF-κB signaling pathway? Animals, 11(11):3151. Doi: 10.3390/ani11113151
Editora
MDPI