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Sighs during sleep in multiple system atrophy

2021Artigo científico Acesso restrito
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dc.contributor.authorParreira, Sara
dc.contributor.authorAntunes, Francisco
dc.contributor.authorCoelho, Miguel
dc.contributor.authorBentes, Carla
dc.contributor.authorPeralta, Ana
dc.date.accessioned2023-01-09T15:07:06Z
dc.date.available2023-01-09T15:07:06Z
dc.date.issued2021
dc.description© 2020 Elsevier B.V. All rights reserved.pt_PT
dc.description.abstractSighs are physiological phenomena and may occasionally occur during sleep in healthy young adults. Although inspiratory sighs are considered a diagnostic red flag for the parkinsonian form of multiple system atrophy (MSA), its frequency and characteristics are unclear. We aimed to define sigh frequency during sleep recordings in patients with MSA compared to Parkinson's disease (PD) patients, as well as evaluate possible associated breathing disorders or autonomic changes. We analyzed 9 polysomnography's from patients with MSA and 9 from matched PD patients. The proportion of MSA patients (both MSA-P and MSA-C) with sleep-related sighs was significantly higher than that of PD patients, and these occurred predominantly in stages N1 and N2. The median sigh index in sleep and wakefulness were also significantly higher in MSA, although with a significant inter-subject variability. Higher sigh indexes were not associated to other breathing disturbances or with longer disease duration. In MSA, 12% of sighs were associated with oxygen desaturation, while none of the events in PD patients presented with significant changes in oxygen saturation. Respiratory events followed 45% of sighs in MSA, predominantly central sleep apneas, and 29% of sighs in PD, predominantly hypopneas. Our data suggests that high sigh frequencies during sleep should also be considered a red flag for MSA, and future studies should aim to determine whether increased sighing frequency during sleep is specific for this disorder.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSleep Med. 2021 Feb;78:75-80pt_PT
dc.identifier.doi10.1016/j.sleep.2020.12.013pt_PT
dc.identifier.eissn1878-5506
dc.identifier.issn1389-9457
dc.identifier.urihttp://hdl.handle.net/10451/55735
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/sleep-medicinept_PT
dc.subjectAtypical parkinsonismpt_PT
dc.subjectMultiple system atrophypt_PT
dc.subjectSigh breathspt_PT
dc.subjectSleep-related breathing disorderspt_PT
dc.titleSighs during sleep in multiple system atrophypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage80pt_PT
oaire.citation.startPage75pt_PT
oaire.citation.titleSleep Medicinept_PT
oaire.citation.volume78pt_PT
person.familyNameParreira
person.familyNameAntunes
person.familyNameCoelho
person.familyNameBentes
person.familyNamePeralta
person.givenNameSara
person.givenNameFrancisco
person.givenNameMiguel
person.givenNameCarla
person.givenNameAna Rita
person.identifier.ciencia-id4D1A-E142-2DF0
person.identifier.ciencia-id3312-A6EB-631D
person.identifier.ciencia-id7D1C-D5DD-C579
person.identifier.ciencia-id1D1D-D037-54D8
person.identifier.orcid0000-0002-2875-1207
person.identifier.orcid0000-0001-7932-1154
person.identifier.orcid0000-0002-4008-8110
person.identifier.orcid0000-0003-2399-7678
person.identifier.orcid0000-0001-9449-431X
person.identifier.scopus-author-id7006648941
person.identifier.scopus-author-id7101666975
person.identifier.scopus-author-id6603395191
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication65be5737-cef5-41ba-803d-e749761ded92
relation.isAuthorOfPublicationa28493a5-9101-4173-8863-74ee946d6ced
relation.isAuthorOfPublicationb1ae9a1f-31c1-42f5-80e0-9383914a671f
relation.isAuthorOfPublication0bc2f877-0ad3-408c-82ee-b5378a014734
relation.isAuthorOfPublicationf365f74e-2a70-4578-9ac1-2f945334c6b0
relation.isAuthorOfPublication.latestForDiscovery65be5737-cef5-41ba-803d-e749761ded92

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