Publication
ESAT-6 a Major Virulence Factor of Mycobacterium tuberculosis
| dc.contributor.author | Anes, Elsa | |
| dc.contributor.author | Pires, David | |
| dc.contributor.author | Mandal, Manoj | |
| dc.contributor.author | Azevedo-Pereira, José Miguel | |
| dc.date.accessioned | 2023-08-24T15:59:29Z | |
| dc.date.available | 2023-08-24T15:59:29Z | |
| dc.date.issued | 2023-06-09 | |
| dc.date.updated | 2023-06-15T13:29:51Z | |
| dc.description.abstract | Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis (TB), is one of the most successfully adapted human pathogens. Human-to-human transmission occurs at high rates through aerosols containing bacteria, but the pathogen evolved prior to the establishment of crowded populations. Mtb has developed a particular strategy to ensure persistence in the host until an opportunity for transmission arises. It has refined its lifestyle to obviate the need for virulence factors such as capsules, flagella, pili, or toxins to circumvent mucosal barriers. Instead, the pathogen uses host macrophages, where it establishes intracellular niches for its migration into the lung parenchyma and other tissues and for the induction of long-lived latency in granulomas. Finally, at the end of the infection cycle, Mtb induces necrotic cell death in macrophages to escape to the extracellular milieu and instructs a strong inflammatory response that is required for the progression from latency to disease and transmission. Common to all these events is ESAT-6, one of the major virulence factors secreted by the pathogen. This narrative review highlights the recent advances in understanding the role of ESAT-6 in hijacking macrophage function to establish successful infection and transmission and its use as a target for the development of diagnostic tools and vaccines. | pt_PT |
| dc.description.sponsorship | The research linked to this work was funded by Fundação para a Ciência e a Tecnologia (FCT) (grant numbers PTDC/SAU-INF/28182/2017 to E.A.; EXPL/SAU-INF/0742/2021 to D.P.; UIDB/04138/2020 to IMed-ULisboa; UIDB/04279/2020 to CIRH; and CEECINST/00070/2021 to Universidade Católica Portuguesa). M.M. is supported by a PhD fellowship from FCT with the reference 2021.07978.BD. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Anes E, Pires D, Mandal M, Azevedo-Pereira JM. ESAT-6 a Major Virulence Factor of Mycobacterium tuberculosis. Biomolecules [Internet]. 2023 Jun 9;13(6):968. Available from: http://dx.doi.org/10.3390/biom13060968 | pt_PT |
| dc.identifier.doi | 10.3390/biom13060968 | pt_PT |
| dc.identifier.slug | cv-prod-3286190 | |
| dc.identifier.uri | http://hdl.handle.net/10451/59007 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | MDPI | pt_PT |
| dc.relation | CEECINST/00070/2021 | pt_PT |
| dc.relation | Development and validation of a 3D cell culture model of the tuberculosis granuloma that can be applied for drug discovery and host cellular studies in the context of a latent infection and multicellular immunologic response. | |
| dc.relation | Research Institute for Medicines | |
| dc.relation | Center for Interdisciplinary Research in Health | |
| dc.relation | Developing host-directed-therapies for Mycobacterium tuberculosis infection and HIV co-infection based on Cystatins manipulation | |
| dc.relation.publisherversion | https://www.mdpi.com/2218-273X/13/6/968 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | tuberculosis | pt_PT |
| dc.subject | ESAT-6 | pt_PT |
| dc.subject | ESX-1 | pt_PT |
| dc.subject | virulence factors | pt_PT |
| dc.subject | PhoPR signal transduction | pt_PT |
| dc.subject | host-pathogen interactions | pt_PT |
| dc.subject | TB vaccines | pt_PT |
| dc.subject | TB diagnosis | pt_PT |
| dc.title | ESAT-6 a Major Virulence Factor of Mycobacterium tuberculosis | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Development and validation of a 3D cell culture model of the tuberculosis granuloma that can be applied for drug discovery and host cellular studies in the context of a latent infection and multicellular immunologic response. | |
| oaire.awardTitle | Research Institute for Medicines | |
| oaire.awardTitle | Center for Interdisciplinary Research in Health | |
| oaire.awardTitle | Developing host-directed-therapies for Mycobacterium tuberculosis infection and HIV co-infection based on Cystatins manipulation | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-INF%2F28182%2F2017/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL%2FSAU-INF%2F0742%2F2021/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04138%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04279%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//2021.07978.BD/PT | |
| oaire.citation.issue | 6 | pt_PT |
| oaire.citation.startPage | 968 | pt_PT |
| oaire.citation.title | Biomolecules | pt_PT |
| oaire.citation.volume | 13 | pt_PT |
| oaire.fundingStream | 3599-PPCDT | |
| oaire.fundingStream | 3599-PPCDT | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| person.familyName | RIBEIRO DOS SANTOS ANES | |
| person.familyName | RODRIGUES PIRES | |
| person.familyName | Mandal | |
| person.familyName | Azevedo Pereira | |
| person.givenName | ELSA MARIA | |
| person.givenName | DAVID ALEXANDRE | |
| person.givenName | Manoj Kumar | |
| person.givenName | José Miguel | |
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| person.identifier.scopus-author-id | 6506539639 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
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| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.cv.cienciaid | 1A10-7DAD-D860 | ELSA MARIA RIBEIRO DOS SANTOS ANES | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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