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A primary role for human central memory cells in tissue immunosurveillance

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dc.contributor.authorGehad, Ahmed
dc.contributor.authorTeague, Jessica E.
dc.contributor.authorMatos, Tiago R.
dc.contributor.authorHuang, Victor
dc.contributor.authorYang, Chao
dc.contributor.authorWatanabe, Rei
dc.contributor.authorO’Malley, John T.
dc.contributor.authorTrimble, Cornelia L.
dc.contributor.authorKupper, Thomas S.
dc.contributor.authorClark, Rachael A.
dc.date.accessioned2021-12-02T15:21:58Z
dc.date.available2021-12-02T15:21:58Z
dc.date.issued2018
dc.description© 2018 by The American Society of Hematologypt_PT
dc.description.abstractCentral memory T cells (TCM) patrol lymph nodes, providing central immunosurveillance against known pathogens, but have not been described as conducting primary tissue immunosurveillance. We analyzed the expression of tissue-homing addressins in human TCM vs effector memory T cells (TEM) from the same donors. In humans, the majority of human TCM were tropic for either skin or gut, and the overall tissue tropism of TCM was comparable to that of TEM TCM were present in healthy, noninflamed human skin, lung, colon, and cervix, suggesting a role for TCM in the primary immunosurveillance of peripheral tissues. TCM also had potent effector functions; 80% of CD8+ TCM produced TC1/TC2/TC17/TC22 cytokines. TCM injected into human skin-grafted mice migrated into skin and induced inflammatory eruptions comparable to TEM-injected mice. In summary, human TCM express peripheral tissue-homing receptors at levels similar to their effector memory counterparts, are found in healthy human tissues, have impressive effector functions, and can act alone to induce skin inflammation in human engrafted mice. Our studies support a novel role for human TCM in primary immunosurveillance of peripheral tissues and highlight the important role of this long-lived cell type in tissue-based immune responses.pt_PT
dc.description.sponsorshipThis work was supported by National Institutes of Health (NIH), National Institute of Arthritis and Musculoskeletal and Skin Diseases grants R01 AR063962 (R.A.C.), R01 AR056720 (R.A.C.), P30 AR069625 (R.A.C.), T32 AR-07098-36 (T.S.K.; supplied salary for J.T.O.), NIH, National Institute of Allergy and Infectious Diseases grant R01 AI097128 (T.S.K. and R.A.C.), NIH, National Cancer Institute grant R01 CA203721 (R.A.C. and T.S.K.), and the AstraZeneca Foundation/Faculty of Medicine of the University of Lisbon Research Grant (T.R.M.).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBlood Adv. 2018 Feb 13;2(3):292-298pt_PT
dc.identifier.doi10.1182/bloodadvances.2017011346pt_PT
dc.identifier.eissn2473-9537
dc.identifier.urihttp://hdl.handle.net/10451/50250
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherASH Publicationspt_PT
dc.relation.publisherversionhttps://ashpublications.org/bloodadvancespt_PT
dc.titleA primary role for human central memory cells in tissue immunosurveillancept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage298pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage292pt_PT
oaire.citation.titleBlood Advancespt_PT
oaire.citation.volume2pt_PT
person.familyNameMatos
person.givenNameTiago R.
person.identifier.orcid0000-0003-2864-8207
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2962860b-b7e5-451c-9d33-ba98d67fd3c3
relation.isAuthorOfPublication.latestForDiscovery2962860b-b7e5-451c-9d33-ba98d67fd3c3

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