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Pleiotropic and potentially beneficial effects of reactive oxygen species on the intracellular signaling pathways in endothelial cells

2021Artigo científico Acesso aberto
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dc.contributor.authorBarvitenko, Nadezhda
dc.contributor.authorSkverchinskaya, Elisaveta
dc.contributor.authorLawen, Alfons
dc.contributor.authorMatteucci, Elena
dc.contributor.authorSaldanha, Carlota
dc.contributor.authorUras, Giuseppe
dc.contributor.authorManca, Alessia
dc.contributor.authorAslam, Muhammad
dc.contributor.authorPantaleo, Antonella
dc.date.accessioned2021-09-23T15:33:16Z
dc.date.available2021-09-23T15:33:16Z
dc.date.issued2021
dc.description© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractEndothelial cells (ECs) are exposed to molecular dioxygen and its derivative reactive oxygen species (ROS). ROS are now well established as important signaling messengers. Excessive production of ROS, however, results in oxidative stress, a significant contributor to the development of numerous diseases. Here, we analyze the experimental data and theoretical concepts concerning positive pro-survival effects of ROS on signaling pathways in endothelial cells (ECs). Our analysis of the available experimental data suggests possible positive roles of ROS in induction of pro-survival pathways, downstream of the Gi-protein-coupled receptors, which mimics insulin signaling and prevention or improvement of the endothelial dysfunction. It is, however, doubtful, whether ROS can contribute to the stabilization of the endothelial barrier.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAntioxidants (Basel). 2021 Jun 3;10(6):904pt_PT
dc.identifier.doi10.3390/antiox10060904pt_PT
dc.identifier.eissn2076-3921
dc.identifier.urihttp://hdl.handle.net/10451/49605
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/journal/antioxidantspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEndothelial cellpt_PT
dc.subjectEndothelial dysfunctionpt_PT
dc.subjectEndothelial paracellular permeabilitypt_PT
dc.subjectInsulin resistancept_PT
dc.subjectReactive oxygen speciespt_PT
dc.titlePleiotropic and potentially beneficial effects of reactive oxygen species on the intracellular signaling pathways in endothelial cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.titleAntioxidantspt_PT
oaire.citation.volume10pt_PT
person.familyNameSaldanha
person.givenNameCarlota
person.identifier53901
person.identifier.orcid0000-0002-5058-2112
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationad6de30c-87ca-4613-bb87-488dd5d285d0
relation.isAuthorOfPublication.latestForDiscoveryad6de30c-87ca-4613-bb87-488dd5d285d0

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