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T follicular regulatory cells keep B cell-directed autoreactivity in check

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The immune system well illustrates the need for balance between aggression and tolerance: mechanisms are needed to drive the production of antibodies effective against pathogens whilst preventing the emergence of antibodies targeting our own cells. T follicular regulatory cells can suppress spontaneous antibody-mediated autoimmunity by vetoing B cell-directed reactivity.

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© The Author(s) under exclusive licence to Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences 2024

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Cell Res. 2024 May;34(5):339-340

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