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Drug desensitizations for chemotherapy: safety and efficacy in preventing anaphylaxis

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dc.contributor.authorCaiado, Joana
dc.contributor.authorCastells, Mariana C.
dc.date.accessioned2021-09-08T13:39:08Z
dc.date.available2021-09-08T13:39:08Z
dc.date.issued2021
dc.description© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021pt_PT
dc.description.abstractHypersensitivity reactions (HSRs) to antineoplastic drugs are increasing due to the expanding use of classical and new drugs in a wide variety of malignancies. PURPOSE OF REVIEW: The goal of this review is to provide current best practices in the diagnosis and management of HSRs based on data and evidence. RECENT FINDINGS: A plethora of studies have provided evidence of the safety and efficacy of rapid drug desensitizations (RDD) to allow for the reintroduction of antineoplastic drugs following an HSR, based on risk stratification. Recently described biomarkers such as basophil activation test, total IgE, BRCA genotyping, and serum IL-6 can aid in guiding improved precision desensitization protocols. Personalized premedication regimens and protocols have improved RDD safety and outcomes. RDD allows for the continued use of chemotherapeutic drugs without impaired drug efficacy. RDD represents the best approach to maintain cancer patients on their most effective treatments.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCurr Allergy Asthma Rep. 2021 Jul 7;21(6):37pt_PT
dc.identifier.doi10.1007/s11882-021-01014-xpt_PT
dc.identifier.eissn1534-6315
dc.identifier.issn1529-7322
dc.identifier.urihttp://hdl.handle.net/10451/49462
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.springer.com/journal/11882pt_PT
dc.subjectChemotherapypt_PT
dc.subjectEndophenotypespt_PT
dc.subjectHypersensitivity reactionspt_PT
dc.subjectMonoclonal antibodiespt_PT
dc.subjectRapid drug desensitizationpt_PT
dc.subjectRisk stratificationpt_PT
dc.titleDrug desensitizations for chemotherapy: safety and efficacy in preventing anaphylaxispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.titleCurrent Allergy and Asthma Reportspt_PT
oaire.citation.volume21pt_PT
person.familyNameCaiado
person.givenNameJoana
person.identifier.orcid0000-0003-3401-7903
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd359c953-5163-4799-8e20-075e461c7b59
relation.isAuthorOfPublication.latestForDiscoveryd359c953-5163-4799-8e20-075e461c7b59

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