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The pseudo-circular genomes of Flaviviruses: structures, mechanisms, and functions of circularization

2021Artigo científico Acesso aberto
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dc.contributor.authorDe Falco, Louis
dc.contributor.authorSilva, Nelly
dc.contributor.authorSantos, Nuno C.
dc.contributor.authorHuber, Roland G.
dc.contributor.authorMartins, Ivo C.
dc.date.accessioned2021-09-16T13:18:39Z
dc.date.available2021-09-16T13:18:39Z
dc.date.issued2021
dc.description© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractThe circularization of viral genomes fulfills various functions, from evading host defense mechanisms to promoting specific replication and translation patterns supporting viral proliferation. Here, we describe the genomic structures and associated host factors important for flaviviruses genome circularization and summarize their functional roles. Flaviviruses are relatively small, single-stranded, positive-sense RNA viruses with genomes of approximately 11 kb in length. These genomes contain motifs at their 5' and 3' ends, as well as in other regions, that are involved in circularization. These motifs are highly conserved throughout the Flavivirus genus and occur both in mature virions and within infected cells. We provide an overview of these sequence motifs and RNA structures involved in circularization, describe their linear and circularized structures, and discuss the proteins that interact with these circular structures and that promote and regulate their formation, aiming to clarify the key features of genome circularization and understand how these affect the flaviviruses life cycle.pt_PT
dc.description.sponsorshipThis research was supported by Fundação para a Ciência e a Tecnologia—Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal) and the Calouste Gulbenkian Foundation (FCG, Portugal) project Science Frontiers Research Prize 2010. N.M.S. acknowledges FCT-MCTES fellowship SFRH/BD/144585/2019. I.C.M. acknowledges FCT-MCTES program “Concurso de Estímulo ao Emprego Científico” (CEECIND/01670/2017).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCells. 2021 Mar 13;10(3):642pt_PT
dc.identifier.doi10.3390/cells10030642pt_PT
dc.identifier.eissn2073-4409
dc.identifier.urihttp://hdl.handle.net/10451/49529
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/journal/cellspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectRNA structurept_PT
dc.subjectCircular RNApt_PT
dc.subjectCircular genomespt_PT
dc.subjectFlaviviruspt_PT
dc.subjectVirus genomespt_PT
dc.titleThe pseudo-circular genomes of Flaviviruses: structures, mechanisms, and functions of circularizationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumber74654
oaire.awardNumber4205
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/74654/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/4205/PT
oaire.citation.issue3pt_PT
oaire.citation.titleCellspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStreamOE
oaire.fundingStreamCEEC IND 2017
person.familyNameCarreira da Silva
person.familyNameSantos
person.familyNameMartins
person.givenNameNelly Marine
person.givenNameNuno
person.givenNameIvo
person.identifier.ciencia-id2A12-ADC2-B73D
person.identifier.ciencia-idCD13-5E3A-A3C5
person.identifier.ciencia-id8C17-BB8B-E8DB
person.identifier.orcid0000-0002-9131-5045
person.identifier.orcid0000-0002-0580-0475
person.identifier.orcid0000-0002-9284-8599
person.identifier.ridN-7248-2013
person.identifier.ridG-2534-2013
person.identifier.scopus-author-id55940818300
person.identifier.scopus-author-id8628164300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication64468330-c2a5-43ca-8b35-fef4621ac09d
relation.isAuthorOfPublication4656d912-5a2d-4c80-8921-2bcba3aa441a
relation.isAuthorOfPublication93078a2a-308d-4285-8592-0ae20057dc09
relation.isAuthorOfPublication.latestForDiscovery64468330-c2a5-43ca-8b35-fef4621ac09d
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