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The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation

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dc.contributor.authorRaposo, Ana Cláudia
dc.contributor.authorCasanova, Miguel
dc.contributor.authorGendrel, Anne-Valerie
dc.contributor.authorda Rocha, Simão T.
dc.date.accessioned2022-01-04T14:01:07Z
dc.date.available2022-01-04T14:01:07Z
dc.date.issued2021
dc.description© 2021 The Author(s) This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).pt_PT
dc.description.abstractX-inactive-specific transcript (Xist) is a long non-coding RNA (lncRNA) essential for X-chromosome inactivation (XCI) in female placental mammals. Thirty years after its discovery, it is still puzzling how this lncRNA triggers major structural and transcriptional changes leading to the stable silencing of an entire chromosome. Recently, a series of studies in mouse cells have uncovered domains of functional specialization within Xist mapping to conserved tandem repeat regions, known as Repeats A-to-F. These functional domains interact with various RNA binding proteins (RBPs) and fold into distinct RNA structures to execute specific tasks in a synergistic and coordinated manner during the inactivation process. This modular organization of Xist is mostly conserved in humans, but recent data point towards differences regarding functional specialization of the tandem repeats between the two species. In this review, we summarize the recent progress on understanding the role of Xist repetitive blocks and their involvement in the molecular mechanisms underlying XCI. We also discuss these findings in the light of the similarities and differences between mouse and human Xist.pt_PT
dc.description.sponsorshipThis work was supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through the project grants PTDC/BIA-MOL/29320/2017 (S.T.d.R. and A.C.R.), and PTDC/BTM-TEC/28534/2017 (M.C.). S.T.d.R. and A.-V. G. are supported by assistant research contracts from FCT/MCTES (CEECIND/01234/2017 and CEECIND/02085/2018, respectively; A.C.R. is supported by a PhD fellowship from FCT/MCTES (SFRH/BD/137099/2018).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBiochem Soc Trans. 2021 Dec 17;49(6):2549-2560pt_PT
dc.identifier.doi10.1042/BST20210253pt_PT
dc.identifier.eissn1470-8752
dc.identifier.issn0300-5127
dc.identifier.urihttp://hdl.handle.net/10451/50688
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPortlands Presspt_PT
dc.relationCEECIND/01234/2017pt_PT
dc.relationCEECIND/02085/2018pt_PT
dc.relationThe role of long non-coding RNAs on the molecular circuitry and metabolic adaptation of breast cancer.
dc.relationFunctional dissection of the XIST non-coding RNA in X-chromosome inactivation in human ESCs
dc.relation.publisherversionhttps://portlandpress.com/biochemsoctranspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectX-chromosome inactivationpt_PT
dc.subjectChromatinpt_PT
dc.subjectEpigeneticspt_PT
dc.subjectlncRNApt_PT
dc.subjectTandem repeatpt_PT
dc.titleThe tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleThe role of long non-coding RNAs on the molecular circuitry and metabolic adaptation of breast cancer.
oaire.awardTitleFunctional dissection of the XIST non-coding RNA in X-chromosome inactivation in human ESCs
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MOL%2F29320%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBTM-TEC%2F28534%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F137099%2F2018/PT
oaire.citation.endPage2560pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage2549pt_PT
oaire.citation.titleBiochemical Society Transactionspt_PT
oaire.citation.volume49pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream9471 - RIDTI
person.familyNameBernardino Raposo
person.familyNameGendrel
person.familyNameTeixeira da Rocha
person.givenNameAna Cláudia
person.givenNameAnne-Valerie
person.givenNameSimão José
person.identifier.ciencia-id5319-3EE3-36F3
person.identifier.ciencia-id1917-59ED-F318
person.identifier.ciencia-id1310-8F0F-1387
person.identifier.orcid0000-0003-4510-0024
person.identifier.orcid0000-0002-9683-7942
person.identifier.ridE-5584-2017
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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