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Health-related quality of life and disability in adults with juvenile idiopathic arthritis: comparison with adult-onset rheumatic diseases

2021Journal article Open access
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dc.contributor.authorOliveira Ramos, Filipa
dc.contributor.authorRodrigues, Ana
dc.contributor.authorMagalhaes Martins, Fernando
dc.contributor.authorMelo, Ana Teresa
dc.contributor.authorAguiar, Francisca
dc.contributor.authorBrites, Luisa
dc.contributor.authorAzevedo, Soraia
dc.contributor.authorDuarte, Ana Catarina
dc.contributor.authorFurtado, Carolina
dc.contributor.authorMourão, Ana Filipa
dc.contributor.authorSequeira, Graça
dc.contributor.authorCunha, Inês
dc.contributor.authorFigueira, Ricardo
dc.contributor.authorMelo Gomes, Jose Antonio
dc.contributor.authorSantos, Maria
dc.contributor.authorFonseca, João Eurico
dc.date.accessioned2023-06-09T14:19:46Z
dc.date.available2023-06-09T14:19:46Z
dc.date.issued2021
dc.description© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.pt_PT
dc.description.abstractObjective: To compare physical disability, mental health, fatigue and health-related quality of life (HRQoL) across juvenile idiopathic arthritis (JIA) categories in adulthood and between JIA and adult-onset rheumatic diseases. Methods: Cross-sectional analysis nested in a cohort of adult patients with JIA registered in the Rheumatic Diseases Portuguese Register (Reuma.pt). Physical disability (Health Assessment Questionnaire-Disability Index), mental health symptoms (Hospital Anxiety and Depression Scale), fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue Scale (FACIT-F)) and HRQoL (EuroQol-5D (EQ5D) and Short Form (SF-36)) were compared across JIA categories. Patients with polyarticular JIA and enthesis-related arthritis (ERA) JIA were compared respectively to patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA), matched for gender and age, adjusted for disease duration and activity. Results: 585 adult patients with JIA were included. Comparison across JIA categories showed that persistent oligoarthritis and patients with ERA reported a higher score in EQ5D and SF-36 physical component when compared with other JIA categories.Polyarticular JIA reported less disability and fatigue than patients with RA (median Health Assessment Questionnaire of 0.25 vs 0.63; p<0.001 and median FACIT-F score 42 vs 40 ; p=0.041). Polyarticular JIA had also better scores on EQ5D and all domains of SF-36, than patients with RA. Patients with ERA reported less depression and anxiety symptoms (0% vs 14.8%; p=0.003% and 9% vs 21.3%; p=0.002) and less fatigue symptoms (45 vs 41; p=0.01) than patients with SpA. Conclusion: Persistent oligoarticular JIA and ERA are the JIA categories in adulthood with better HRQoL. Overall, adult polyarticular and patients with ERA JIA have lower functional impairment and better quality-of-life than patients with RA and SpA.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRMD Open. 2021 Nov;7(3):e001766pt_PT
dc.identifier.doi10.1136/rmdopen-2021-001766pt_PT
dc.identifier.eissn2056-5933
dc.identifier.urihttp://hdl.handle.net/10451/58148
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Grouppt_PT
dc.relation.publisherversionhttps://rmdopen.bmj.com/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAnkylosingpt_PT
dc.subjectArthritispt_PT
dc.subjectJuvenilept_PT
dc.subjectPatient reported outcome measurespt_PT
dc.subjectRheumatoidpt_PT
dc.subjectSpondylitispt_PT
dc.titleHealth-related quality of life and disability in adults with juvenile idiopathic arthritis: comparison with adult-onset rheumatic diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.titleRMD Openpt_PT
oaire.citation.volume7pt_PT
person.familyNameOliveira Ramos
person.familyNameMelo
person.familyNameSantos
person.familyNameFonseca
person.givenNameFilipa
person.givenNameAna Teresa
person.givenNameMaria Jose
person.givenNameJoão
person.identifier.ciencia-id251C-6C68-CDF7
person.identifier.ciencia-id441A-CD98-8FD6
person.identifier.ciencia-idF310-B85D-57C7
person.identifier.orcid0000-0001-7132-8909
person.identifier.orcid0000-0002-7904-0683
person.identifier.orcid0000-0002-7946-1365
person.identifier.orcid0000-0003-1432-3671
person.identifier.scopus-author-id7101983519
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication6f0bb1d2-8b88-4cbc-afb2-cbf1be1a1e8c
relation.isAuthorOfPublicationf7c2f8ee-54b9-40d6-a39a-a31083a5f193
relation.isAuthorOfPublication288e25e9-3f56-4cab-afff-0cda5478f1ba
relation.isAuthorOfPublication1772dc12-7c55-4c76-ae2d-c23270172480
relation.isAuthorOfPublication.latestForDiscoveryf7c2f8ee-54b9-40d6-a39a-a31083a5f193

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