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Emergence of Optochin resistance among Streptococcus pneumoniae in Portugal

2006Artigo científico Acesso restrito
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dc.contributor.authorAguiar, Sandra I
dc.contributor.authorFrias, Maria João
dc.contributor.authorSantos, Letícia
dc.contributor.authorMelo Cristino, José
dc.contributor.authorRamirez, Mário
dc.date.accessioned2021-05-10T16:52:19Z
dc.date.available2021-05-10T16:52:19Z
dc.date.issued2006
dc.descriptionCopyright 2006, Mary Ann Liebert, Inc.pt_PT
dc.description.abstractIn most clinical microbiology laboratories optochin susceptibility is used in the screening and identification of Streptococcus pneumoniae. We report the characterization of 32 optochin-resistant S. pneumoniae strains from 10 laboratories that constituted 3.2% of all isolates recovered in 2005 in 30 laboratories in Portugal. Resistant isolates consisted of bile-soluble optochin-susceptible and optochin-resistant subpopulations with identical antimicrobial susceptibility patterns, capsular types and pulsed-field gel electrophoresis (PFGE) profiles. The most frequent serotypes—1, 19A, 11A, 3, 8, and 15A—were all common serotypes present in infection and colonization isolates in the country. The PFGE profiles of the 32 isolates corresponded to those of previously identified clones and confirmed that the emergence of these strains could not be attributed to clonal expansion. Clinical laboratories must be aware that optochin-resistant pneumococci are presently circulating in the community. Because accurate identification of S. pneumoniae is essential for correct diagnosis and adequate therapy of patients, we recommend that at least the bile solubility test should be routinely performed in cases of suspected pneumococcal etiology, even if the isolates are optochin-resistant.pt_PT
dc.description.sponsorshipThis work was partly supported by contract LSHM-CT-2003-503413 (Pneumococcal Resistance Epidemicity and Virulence—an International Study) (PREVIS) from the EuropeanComission, by the Fundação para a Ciência e Tecnologia (POCTI/ESP/47914), and by an unrestricted grant from Glaxo-SmithKline Portugal.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMicrob Drug Resist. 2006 Winter;12(4):239-245pt_PT
dc.identifier.doi10.1089/mdr.2006.12.239pt_PT
dc.identifier.eissn1931-8448
dc.identifier.issn1076-6294
dc.identifier.urihttp://hdl.handle.net/10451/47733
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMary Ann Liebert, Inc.pt_PT
dc.relationLSHM-CT-2003-503413pt_PT
dc.relationPneumococcal phase transition between colonization and disease
dc.relation.publisherversionhttps://home.liebertpub.com/publications/microbial-drug-resistance/44pt_PT
dc.titleEmergence of Optochin resistance among Streptococcus pneumoniae in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPOCTI/ESP/47914/2002
oaire.awardTitlePneumococcal phase transition between colonization and disease
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCTI%2FESP%2F47914%2F2002/PT
oaire.citation.endPage245pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage239pt_PT
oaire.citation.titleMicrobial Drug Resistancept_PT
oaire.citation.volume12pt_PT
oaire.fundingStreamPOCI
person.familyNameAguiar
person.familyNameFrias
person.familyNameMelo Cristino
person.familyNameRamos de Almeida Ramirez
person.givenNameSandra
person.givenNameMaria João
person.givenNameJosé
person.givenNameMário Nuno
person.identifierA-3500-2009
person.identifierB-4993-2008
person.identifier.ciencia-id8E10-C536-8517
person.identifier.ciencia-idE514-2540-A5A6
person.identifier.ciencia-id871E-6AD6-F37C
person.identifier.ciencia-id9C1C-F2A2-4226
person.identifier.orcid0000-0002-3041-383X
person.identifier.orcid0000-0002-8060-1206
person.identifier.orcid0000-0001-8643-1722
person.identifier.orcid0000-0002-4084-6233
person.identifier.ridH-3726-2013
person.identifier.scopus-author-id15765061800
person.identifier.scopus-author-id7004053640
person.identifier.scopus-author-id7201568476
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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