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Association of body mass index and Parkinson disease

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dc.contributor.authorDomenighetti, Cloé
dc.contributor.authorSugier, Pierre-Emmanuel
dc.contributor.authorAshok Kumar Sreelatha, Ashwin
dc.contributor.authorSchulte, Claudia
dc.contributor.authorGrover, Sandeep
dc.contributor.authorPortugal, Berta
dc.contributor.authorLee, Pei-Chen
dc.contributor.authorMay, Patrick
dc.contributor.authorBobbili, Dheeraj
dc.contributor.authorRadivojkov Blagojevic, Milena
dc.contributor.authorLichtner, Peter
dc.contributor.authorSingleton, Andrew B.
dc.contributor.authorHernandez, Dena
dc.contributor.authorEdsall, Connor
dc.contributor.authorMellick, George D.
dc.contributor.authorZimprich, Alexander A.
dc.contributor.authorPirker, Walter
dc.contributor.authorRogaeva, Ekaterina A.
dc.contributor.authorLang, Anthony E.
dc.contributor.authorKoks, Sulev
dc.contributor.authorTaba, Pille
dc.contributor.authorLesage, Suzanne
dc.contributor.authorBrice, Alexis
dc.contributor.authorCorvol, Jean-Christophe
dc.contributor.authorChartier-Harlin, Marie-Christine
dc.contributor.authorMutez, Eugenie
dc.contributor.authorBrockmann, Kathrin
dc.contributor.authorDeutschlander, Angela B.
dc.contributor.authorHadjigeorgiou, Georgios M.
dc.contributor.authorDardiotis, Efthimios
dc.contributor.authorStefanis, Leonidas
dc.contributor.authorSimitsi, Athina Maria
dc.contributor.authorValente, Enza Maria
dc.contributor.authorPetrucci, Simona
dc.contributor.authorStraniero, Letizia
dc.contributor.authorZecchinelli, Anna L.
dc.contributor.authorPezzoli, Gianni
dc.contributor.authorBrighina, Laura
dc.contributor.authorFerrarese, Carlo
dc.contributor.authorAnnesi, Grazia
dc.contributor.authorQuattrone, Andrea
dc.contributor.authorGagliardi, Monica
dc.contributor.authorMatsuo, Hirotaka
dc.contributor.authorNakayama, Akiyoshi
dc.contributor.authorHattori, Nobutaka
dc.contributor.authorNishioka, Kenya
dc.contributor.authorChung, Sun Ju
dc.contributor.authorKim, Yun Joong
dc.contributor.authorKolber, Pierre
dc.contributor.authorVan De Warrenburg, Bart P.C.
dc.contributor.authorBloem, Bastiaan R.
dc.contributor.authorToft, Mathias
dc.contributor.authorPihlstrøm, Lasse
dc.contributor.authorCorreia Guedes, Leonor
dc.contributor.authorFerreira, Joaquim J
dc.contributor.authorBardien, Soraya
dc.contributor.authorCarr, Jonathan
dc.contributor.authorTolosa, Eduardo
dc.contributor.authorEzquerra, Mario
dc.contributor.authorPastor, Pau
dc.contributor.authorDiez-Fairen, Monica
dc.contributor.authorWirdefeldt, Karin
dc.contributor.authorPedersen, Nancy L.
dc.contributor.authorRan, Caroline
dc.contributor.authorBelin, Andrea C.
dc.contributor.authorPuschmann, Andreas
dc.contributor.authorHellberg, Clara
dc.contributor.authorClarke, Carl E.
dc.contributor.authorMorrison, Karen E.
dc.contributor.authorTan, Manuela M.
dc.contributor.authorKrainc, Dimitri
dc.contributor.authorBurbulla, Lena F.
dc.contributor.authorFarrer, Matthew
dc.contributor.authorKruger, Rejko
dc.contributor.authorGasser, Thomas
dc.contributor.authorSharma, Manu
dc.contributor.authorElbaz, Alexis
dc.date.accessioned2024-07-24T13:56:17Z
dc.date.available2024-07-24T13:56:17Z
dc.date.issued2024
dc.description© American Academy of Neurology. Copyright © 2024, Wolters Kluwer Healthpt_PT
dc.description.abstractBackground and objectives: The role of body mass index (BMI) in Parkinson disease (PD) is unclear. Based on the Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in PD (Courage-PD) consortium, we used 2-sample Mendelian randomization (MR) to replicate a previously reported inverse association of genetically predicted BMI with PD and investigated whether findings were robust in analyses addressing the potential for survival and incidence-prevalence biases. We also examined whether the BMI-PD relation is bidirectional by performing a reverse MR. Methods: We used summary statistics from a genome-wide association study (GWAS) to extract the association of 501 single-nucleotide polymorphisms (SNPs) with BMI and from the Courage-PD and international Parkinson Disease Genomics Consortium (iPDGC) to estimate their association with PD. Analyses are based on participants of European ancestry. We used the inverse-weighted method to compute odds ratios (ORIVW per 4.8 kg/m2 [95% CI]) of PD and additional pleiotropy robust methods. We performed analyses stratified by age, disease duration, and sex. For reverse MR, we used SNPs associated with PD from 2 iPDGC GWAS to assess the effect of genetic liability toward PD on BMI. Results: Summary statistics for BMI are based on 806,834 participants (54% women). Summary statistics for PD are based on 8,919 (40% women) cases and 7,600 (55% women) controls from Courage-PD, and 19,438 (38% women) cases and 24,388 (51% women) controls from iPDGC. In Courage-PD, we found an inverse association between genetically predicted BMI and PD (ORIVW 0.82 [0.70-0.97], p = 0.012) without evidence for pleiotropy. This association tended to be stronger in younger participants (≤67 years, ORIVW 0.71 [0.55-0.92]) and cases with shorter disease duration (≤7 years, ORIVW 0.75 [0.62-0.91]). In pooled Courage-PD + iPDGC analyses, the association was stronger in women (ORIVW 0.85 [0.74-0.99], p = 0.032) than men (ORIVW 0.92 [0.80-1.04], p = 0.18), but the interaction was not statistically significant (p-interaction = 0.48). In reverse MR, there was evidence for pleiotropy, but pleiotropy robust methods showed a significant inverse association. Discussion: Using an independent data set (Courage-PD), we replicate an inverse association of genetically predicted BMI with PD, not explained by survival or incidence-prevalence biases. Moreover, reverse MR analyses support an inverse association between genetic liability toward PD and BMI, in favor of a bidirectional relation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNeurology. 2024 Aug 13;103(3):e209620pt_PT
dc.identifier.doi10.1212/WNL.0000000000209620pt_PT
dc.identifier.eissn1526-632X
dc.identifier.issn0028-3878
dc.identifier.urihttp://hdl.handle.net/10451/65456
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWolters Kluwerpt_PT
dc.relation.publisherversionhttps://www.neurology.org/journal/wnlpt_PT
dc.titleAssociation of body mass index and Parkinson diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.titleNeurologypt_PT
oaire.citation.volume103pt_PT
person.familyNameCorreia Guedes
person.familyNameFerreira
person.givenNameLeonor
person.givenNameJoaquim J
person.identifier1624753
person.identifier.ciencia-id1518-348B-19BD
person.identifier.ciencia-id7D15-5CD6-6159
person.identifier.orcid0000-0002-8422-0494
person.identifier.orcid0000-0003-3950-5113
person.identifier.scopus-author-id7403252466
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc67bea09-55ea-4363-804e-0b8cb194da4a
relation.isAuthorOfPublication54d84fe7-2cbd-4ddc-bce2-0ff2bd7c4cc9
relation.isAuthorOfPublication.latestForDiscoveryc67bea09-55ea-4363-804e-0b8cb194da4a

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