Publicação
Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART)
| dc.contributor.author | Policicchio, Benjamin Bruno | |
| dc.contributor.author | Sette, Paola | |
| dc.contributor.author | Xu, Cuiling | |
| dc.contributor.author | Haret-Richter, George | |
| dc.contributor.author | Dunsmore, Tammy | |
| dc.contributor.author | Pandrea, Ivona | |
| dc.contributor.author | Ribeiro, Ruy M. | |
| dc.contributor.author | Apetrei, Cristian | |
| dc.date.accessioned | 2020-12-03T17:52:13Z | |
| dc.date.available | 2020-12-03T17:52:13Z | |
| dc.date.issued | 2018 | |
| dc.description | Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. | pt_PT |
| dc.description.abstract | Two SIVmac251-infected rhesus macaques received tenofovir/emtricitabine with raltegravir intensification. Viral rebound occurred during treatment and sequencing of reverse transcriptase and integrase genes identified multiple resistance mutations. Similar to HIV infection, antiretroviral-resistance mutations may occur in SIV-infected nonhuman primates receiving nonsuppressive ART. As ART administration to nonhuman primates is currently dramatically expanding, fueled by both cure research and the study of HIV-related comorbidities, viral resistance should be factored in the study design and data interpretation. | pt_PT |
| dc.description.sponsorship | This research was funded through National Institutes of Health /National Institute of Allergy and Infectious Diseases / National Heart, Lung and Blood Institute grants R01 AI104373 (RMR), RO1 HL117715 (IP), R01 AI119346 (CA) and R01 HL123096 (IP). BBP was supported by the NIH Training Grant T32 AI065380. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | PLoS ONE 13(2): e0190908. | pt_PT |
| dc.identifier.doi | 10.1371/journal.pone.0190908 | pt_PT |
| dc.identifier.eissn | 1932-6203 | |
| dc.identifier.uri | http://hdl.handle.net/10451/45119 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | PLOS | pt_PT |
| dc.relation.publisherversion | https://journals.plos.org/ | pt_PT |
| dc.title | Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART) | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 2 | pt_PT |
| oaire.citation.startPage | e0190908 | pt_PT |
| oaire.citation.title | PloS One | pt_PT |
| oaire.citation.volume | 13 | pt_PT |
| person.familyName | Ribeiro | |
| person.givenName | Ruy Miguel | |
| person.identifier.ciencia-id | 9A15-E40B-738F | |
| person.identifier.orcid | 0000-0002-3988-8241 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 215b5cf4-faab-41ea-becf-c63bed56d3d1 | |
| relation.isAuthorOfPublication.latestForDiscovery | 215b5cf4-faab-41ea-becf-c63bed56d3d1 |
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