Logo do repositório
 
Publicação

Translational oncotargets for immunotherapy : from pet dogs to humans

2021Artigo científico Acesso restrito
Ver registo simples
dc.contributor.authorMestrinho, Lisa A.
dc.contributor.authorSantos, Ricardo
dc.date.accessioned2021-05-14T11:19:00Z
dc.date.available2021-05-14T11:19:00Z
dc.date.issued2021
dc.description© 2021 Elsevier B.V. All rights reserved.pt_PT
dc.description.abstractPreclinical studies in rodent models have been a pivotal role in human clinical research, but many of them fail in the translational process. Spontaneous tumors in pet dogs have the potential to bridge the gap between preclinical models and human clinical trials. Their natural occurrence in an immunocompetent system overcome the limitations of preclinical rodent models. Due to its reasonable cellular, molecular, and genetic homology to humans, the pet dog represents a valuable model to accelerate the translation of preclinical studies to clinical trials in humans, actually with benefits for both species. Moreover, their unique genetic features of breeding and breed-related mutations have contributed to assess and optimize therapeutics in individuals with different genetic backgrounds. This review aims to outline four main immunotherapy approaches - cancer vaccines, adaptive T-cell transfer, antibodies, and cytokines -, under research in veterinary medicine and how they can serve the clinical application crosstalk with humans.pt_PT
dc.description.sponsorshipThis work was supported by FCT - Fundação para a Ciência e Tecnologia IP, grant UIDB/00276/2020, from CIISA – Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Portugal.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAdv Drug Deliv Rev. 2021 May;172:296-313pt_PT
dc.identifier.doi10.1016/j.addr.2021.02.020pt_PT
dc.identifier.eissn1872-8294
dc.identifier.issn0169-409X
dc.identifier.urihttp://hdl.handle.net/10451/47854
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationCentre for Interdisciplinary Research in Animal Health
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/advanced-drug-delivery-reviewspt_PT
dc.subjectCancer modelpt_PT
dc.subjectComparative oncologypt_PT
dc.subjectImmunotherapypt_PT
dc.subjectPet dogpt_PT
dc.subjectTumor antigenspt_PT
dc.titleTranslational oncotargets for immunotherapy : from pet dogs to humanspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/00276/2020
oaire.awardTitleCentre for Interdisciplinary Research in Animal Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00276%2F2020/PT
oaire.citation.endPage313pt_PT
oaire.citation.startPage296pt_PT
oaire.citation.titleAdvanced Drug Delivery Reviewspt_PT
oaire.citation.volume172pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMestrinho
person.familyNameSantos
person.givenNameLisa
person.givenNameRicardo
person.identifier139537
person.identifier.ciencia-id0F18-F2CD-18D4
person.identifier.orcid0000-0002-2424-2106
person.identifier.orcid0000-0003-0406-4215
person.identifier.ridF-2974-2014
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationfc1ff18e-26cd-44a2-b698-9ab26239fcb4
relation.isAuthorOfPublicationa5cb2262-dbd8-4c4f-a22f-f4ad19632af9
relation.isAuthorOfPublication.latestForDiscoverya5cb2262-dbd8-4c4f-a22f-f4ad19632af9
relation.isProjectOfPublication8563a044-0c86-49a8-a275-8b1bb62cc0d8
relation.isProjectOfPublication.latestForDiscovery8563a044-0c86-49a8-a275-8b1bb62cc0d8

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
Translational_oncotargets.pdf
Tamanho:
884.55 KB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

FM-ISAMB-Artigos em Revistas Internacionais