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The mechanisms and quantification of the selective permeability in transport across biological barriers : the example of kyotorphin

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dc.contributor.authorSerrano, Isa D.
dc.contributor.authorFreire, João M.
dc.contributor.authorCarvalho, Miguel V.
dc.contributor.authorNeves, Mafalda
dc.contributor.authorMelo, Manuel N.
dc.contributor.authorCastanho, Miguel A. R. B.
dc.date.accessioned2016-04-19T13:35:33Z
dc.date.available2016-04-19T13:35:33Z
dc.date.issued2014
dc.description© 2014 Bentham Science Publisherspt_PT
dc.description.abstractThis paper addresses the mechanisms behind selective endothelial permeability and their regulations. The singular properties of each of the seven blood-tissues barriers. Then, it further revisits the physical, quantitative meaning of permeability, and the way it should be measured based on sound physical chemistry reasoning and methodologies. Despite the relevance of permeability studies one often comes across inaccurate determinations, mostly from oversimplified data analyses. To worsen matters, the exact meaning of permeability is being lost along with this loss of accuracy. The importance of proper permeability calculation is illustrated with a family of derivatives of kyotorphin, an analgesic dipeptide.pt_PT
dc.description.sponsorshipThe authors thank to Fundação para a Ciência e Tecnologia – Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal) and EC-FP7 Marie Curie Industry-Academia Partnerships and Pathways (IAPP), Grant nº 230654 – Pep2Brain for financial support to the projects PTDC/QUI/69937/2006 and PTDC/QUI-BIQ/112929/2009. FCT-MCTES is also acknowledged for funding Post-doc fellowship SFRH/BPD/37998/2007 to I. Serrano and PhD fellowship SFRH/BD/70423/2010 to J. Freire.pt_PT
dc.identifier.citationMini-Reviews in Medicinal Chemistry, 2014, 14, 99-110pt_PT
dc.identifier.doi10.2174/1389557514666140123130058pt_PT
dc.identifier.issn1389-5575
dc.identifier.urihttp://hdl.handle.net/10451/23447
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBentham Science Publisherspt_PT
dc.relationThe role of lipid membranes in Dengue virus cell infection
dc.relationGENOMIC AND EPI-GENOMIC EFFECTS OF THERMAL STRESS IN VITIS VINIFERA
dc.relation.publisherversionhttp://benthamscience.com/journals/mini-reviews-in-medicinal-chemistry/pt_PT
dc.subjectBlood-tissue barrierspt_PT
dc.subjectDrugpt_PT
dc.subjectKineticspt_PT
dc.subjectKyotorphinpt_PT
dc.subjectPermeabilitypt_PT
dc.subjectTransepithelial transportpt_PT
dc.titleThe mechanisms and quantification of the selective permeability in transport across biological barriers : the example of kyotorphinpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleThe role of lipid membranes in Dengue virus cell infection
oaire.awardTitleGENOMIC AND EPI-GENOMIC EFFECTS OF THERMAL STRESS IN VITIS VINIFERA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI%2F69937%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-BIQ%2F112929%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F37998%2F2007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F70423%2F2010/PT
oaire.citation.titleMini-Reviews in Medicinal Chemistrypt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationc58bec02-7835-45b4-9342-bd8c51988ce7
relation.isProjectOfPublication954cb0bb-03f8-45f6-a48d-27c88a2f8690
relation.isProjectOfPublicatione7f990df-2342-49b5-b449-4f972291ac40
relation.isProjectOfPublication1a004e63-0ace-4b41-bd0c-db90b919807e
relation.isProjectOfPublication.latestForDiscoverye7f990df-2342-49b5-b449-4f972291ac40

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