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Advances in Bioprocess Engineering for Optimising Chlorella vulgaris Fermentation: Biotechnological Innovations and Applications
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Orientador(es)
Resumo(s)
Chlorella vulgaris, a unicellular green microalga, has obtained significant attention due to
its high protein content, abundance of bioactive compounds, and broad biotechnological potential.
Used in nutraceuticals, pharmaceuticals, and functional foods, it is now gaining traction in cosmet-
ics, biopharmaceuticals, and environmental applications. Recent advancements in fermentation
technology, such as the development of high-density fermentation strategies, adaptive evolution
of strains, and real-time monitoring systems, have greatly improved the efficiency, scalability, and
sustainability of C. vulgaris production, enhancing bioavailability and product quality. This review
explores developments in C. vulgaris fermentation, highlighting advancements in strain improve-
ment through genetic engineering, metabolic optimization, mutagenesis, and adaptive evolution,
alongside bioprocess engineering and the optimization of fermentation parameters. Key considera-
tions include bioreactor design, downstream processing, and innovative monitoring technologies
aimed at maximizing biomass yield and bioactive compound production. Emerging applications of
fermented C. vulgaris across industries are also highlighted, along with future perspectives on scaling
up production, addressing regulatory challenges, and ensuring biosafety. These insights provide a
comprehensive outlook on the future of C. vulgaris fermentation in biotechnological applications.
Descrição
Palavras-chave
Chlorella vulgaris microalgae fermentation bioprocess optimization strain improvement bioreactors biopharmaceuticals bioactive compounds functional foods
Contexto Educativo
Citação
Mendes, A.R.; Spínola, M.P.; Lordelo, M.; Prates, J.A.M. Advances in Bioprocess Engineering for Optimising Chlorella vulgaris Fermentation: Biotechnological Innovations and Applications. Foods 2024, 13, 4154. https://doi.org/10.3390/foods13244154
Editora
MDPI