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Relationship between intraocular pressure and anterior lamina cribrosa depth : a cross-sectional observational study in a healthy Portuguese population

2017-05-11Journal article Restricted access
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dc.contributor.authorSousa, David Cordeiro
dc.contributor.authorLeal, Ines
dc.contributor.authorMarques-Neves, Carlos
dc.contributor.authorPinto, Filomena
dc.contributor.authorPinto, Luis
dc.date.accessioned2020-12-09T18:27:03Z
dc.date.available2020-12-09T18:27:03Z
dc.date.issued2017-05-11
dc.descriptionCopyright © 2017, © SAGE Publicationspt_PT
dc.description.abstractPurpose: To investigate the association between anterior lamina cribrosa depth (ALCD), determined with enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT), and intraocular pressure (IOP) in a healthy Portuguese population. Methods: In this cross-sectional observational study conducted between January and July 2015, 2 optic nerve head (ONH)-centered EDI-OCT cross-scans were performed and ALCD was defined as the perpendicular distance between the line connecting both edges of Bruch's membrane opening and the anterior border of the lamina cribrosa at the maximum depth point. A multivariate regression model was performed to assess the association of IOP and ALCD. Results: The studied population included 59 subjects (35 women) with a mean age of 61.7 ± 15.1 years. Mean vertical and horizontal maximum ALCD was 444.5 ± 92.2 μm and 427.6 ± 82.7 μm, respectively. When controlling for age and spherical equivalent, maximum vertical and horizontal ALCD were positively correlated with intraocular pressure (R2>0.20) by 8.58 μm (95% confidence interval [CI] 2.80-14.36 μm; p<0.01) and 8.25 μm (95% CI 2.71-13.78 μm; p<0.01) per mm Hg of IOP, respectively. Conclusions: Our sample of healthy subjects presented a statistically significant positive correlation between IOP and ALCD when controlling for possible confounding factors. These results may trigger further studies to better elucidate the role of IOP in the morphologic and functional dynamics of the ONH.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Ophthalmol. 2017 May 11;27(3):295-300pt_PT
dc.identifier.doi10.5301/ejo.5000867pt_PT
dc.identifier.eissn1724-6016
dc.identifier.issn1120-6721
dc.identifier.urihttp://hdl.handle.net/10451/45215
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSAGE Publicationspt_PT
dc.relation.publisherversionhttps://journals.sagepub.com/home/ejopt_PT
dc.subjectAnterior lamina cribrosa surface depthpt_PT
dc.subjectEnhanced depth imaging ocular coherence tomographypt_PT
dc.subjectIntraocular pressurept_PT
dc.subjectMultivariate regressionpt_PT
dc.subjectOptic nerve headpt_PT
dc.titleRelationship between intraocular pressure and anterior lamina cribrosa depth : a cross-sectional observational study in a healthy Portuguese populationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage300pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage295pt_PT
oaire.citation.titleEuropean journal of ophthalmologypt_PT
oaire.citation.volume27pt_PT
person.familyNameSousa
person.familyNameLeal
person.familyNameMarques Neves
person.familyNameAbegão Pinto
person.givenNameDavid Cordeiro
person.givenNameInes
person.givenNameCarlos
person.givenNameLuis
person.identifier707480
person.identifier.ciencia-idDF1D-9635-8FC4
person.identifier.ciencia-idCD11-9FB8-5416
person.identifier.ciencia-idC119-D580-13D6
person.identifier.ciencia-idF216-4AFA-8E65
person.identifier.orcid0000-0002-7680-0325
person.identifier.orcid0000-0001-9622-8779
person.identifier.orcid0000-0002-3842-2466
person.identifier.orcid0000-0002-9960-7579
person.identifier.ridA-6192-2015
person.identifier.scopus-author-id57188627862
person.identifier.scopus-author-id57187966600
person.identifier.scopus-author-id6504812918
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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