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The circulating non-coding RNA landscape for biomarker research : lessons and prospects from cardiovascular diseases

dc.contributor.authorStępień, Ewa
dc.contributor.authorCosta, Marina C.
dc.contributor.authorKurc, Szczepan
dc.contributor.authorDrożdż, Anna
dc.contributor.authorCortez-Dias, Nuno
dc.contributor.authorEnguita, Francisco J.
dc.date.accessioned2019-07-19T10:56:55Z
dc.date.available2019-07-19T10:56:55Z
dc.date.issued2018-07
dc.description© 2018 Springer Nature Publishing AGpt_PT
dc.description.abstractPervasive transcription of the human genome is responsible for the production of a myriad of non-coding RNA molecules (ncRNAs) some of them with regulatory functions. The pivotal role of ncRNAs in cardiovascular biology has been unveiled in the last decade, starting from the characterization of the involvement of micro-RNAs in cardiovascular development and function, and followed by the use of circulating ncRNAs as biomarkers of cardiovascular diseases. The human non-coding secretome is composed by several RNA species that circulate in body fluids and could be used as biomarkers for diagnosis and outcome prediction. In cardiovascular diseases, secreted ncRNAs have been described as biomarkers of several conditions including myocardial infarction, cardiac failure, and atrial fibrillation. Among circulating ncRNAs, micro-RNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) have been proposed as biomarkers in different cardiovascular diseases. In comparison with standard biomarkers, the biochemical nature of ncRNAs offers better stability and flexible storage conditions of the samples, and increased sensitivity and specificity. In this review we describe the current trends and future prospects of the use of the ncRNA secretome components as biomarkers of cardiovascular diseases, including the opening questions related with their secretion mechanisms and regulatory actions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationActa Pharmacol Sin. 2018 Jul;39(7):1085-1099pt_PT
dc.identifier.doi10.1038/aps.2018.35pt_PT
dc.identifier.issn1671-4083
dc.identifier.urihttp://hdl.handle.net/10451/39188
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Nature [academic journals on nature.com]pt_PT
dc.relation.publisherversionhttps://www.nature.com/aps/pt_PT
dc.subjectAtrial fibrillationpt_PT
dc.subjectBiomarkerpt_PT
dc.subjectCardiac failurept_PT
dc.subjectCardiovascular diseasespt_PT
dc.subjectcircRNApt_PT
dc.subjectCirculating ncRNApt_PT
dc.subjectlncRNApt_PT
dc.subjectmiRNApt_PT
dc.subjectMyocardial infarctionpt_PT
dc.titleThe circulating non-coding RNA landscape for biomarker research : lessons and prospects from cardiovascular diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1099pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage1085pt_PT
oaire.citation.titleActa Pharmacologica Sinicapt_PT
oaire.citation.volume39pt_PT
person.familyNameCosta
person.familyNameCortez-Dias
person.familyNameEnguita
person.givenNameMarina
person.givenNameNuno
person.givenNameFrancisco J.
person.identifier173306
person.identifier.ciencia-id6818-7810-6CEC
person.identifier.ciencia-idD612-D3C3-6E1D
person.identifier.ciencia-idB215-8D49-3218
person.identifier.orcid0000-0001-9020-7539
person.identifier.orcid0000-0002-9244-4631
person.identifier.orcid0000-0002-8072-8557
person.identifier.ridO-1710-2014
person.identifier.ridA-2347-2009
person.identifier.scopus-author-id55453276400
person.identifier.scopus-author-id6602119231
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc4dcab9e-b873-4587-bb30-5203af150404
relation.isAuthorOfPublication36f4a32d-38e4-4c28-9140-4ba468059a22
relation.isAuthorOfPublicationa101dbd4-6bf5-4546-882e-e2596eddb6b4
relation.isAuthorOfPublication.latestForDiscovery36f4a32d-38e4-4c28-9140-4ba468059a22

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