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Polifenóis e doenças inflamatórias: potencial dos compostos polifenólicos nas Doenças Inflamatórias do Intestino
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Resumo(s)
Os polifenóis são compostos abundantemente encontrados no reino vegetal que têm sido descritos, em vários estudos, como tendo propriedades benéficas para a saúde humana. Por isso, estes compostos têm apresentado um interesse crescente ao longo dos anos e têm sido alvo de muita investigação. Uma das propriedades mais exploradas no campo científico é a sua acção anti-inflamatória. Vários estudos e artigos de revisão referem que a actividade anti-inflamatória dos polifenóis se deve à sua capacidade de modular cascatas de sinalização e, consequentemente, mediadores inflamatórios. Desta forma, crê-se que estes compostos sejam capazes de suprimir a inflamação, incluindo a inflamação crónica que caracteriza muitas doenças, como as Doenças Inflamatórias do Intestino.
As Doenças Inflamatórias do Intestino (DII), caracterizadas por uma inflamação intestinal crónica com episódios de remissão, são patologias relativamente frequentes nos países desenvolvidos. De acordo com vários estudos clínicos, alguns polifenóis têm a capacidade de inibir enzimas das cascatas de sinalização em modelos de células intestinais, diminuir as recidivas das Doenças Inflamatórias do Intestino e melhorar lesões intestinais em estudos in vivo.
Esta monografia aborda a temática dos polifenóis, as suas potencialidades como modulador das cascatas de sinalização e as suas finalidades promissoras como terapêutica adjuvante nos doentes com DII.
Polyphenols are compounds ubiquitously found in plants which were described as having beneficial properties for human health. These compounds increasingly gained interest over the years, being the main subject of of several studies. One of the mainly properties explored in the scientific field is their anti-inflammatory activity. Many studies and reviews provided evidence that polyphenols can effectively decrease inflammation by modulating signaling pathways and inflammatory mediators. Thus, it is believed that these compounds are able to suppress chronic inflammation that characterizes many diseases like inflammatory bowel diseases. Inflammatory bowel diseases are characterized by chronic intestinal inflammation, intermittent episodes of clinical remission and relapse and are relatively common in developed countries. According to some studies, some polyphenols have the ability to inhibit molecules from signaling cascades in intestinal cell models. Furthermore, some clinical trials also suggest that these phenolic compounds decrease the number of relapses in ulcerative colitis patients and improve intestinal lesions in in vivo studies. This review addresses some facts about polyphenols, their potential as modulator of signaling cascades and their promising future as adjunctive therapy in patients with inflammatory bowel diseases.
Polyphenols are compounds ubiquitously found in plants which were described as having beneficial properties for human health. These compounds increasingly gained interest over the years, being the main subject of of several studies. One of the mainly properties explored in the scientific field is their anti-inflammatory activity. Many studies and reviews provided evidence that polyphenols can effectively decrease inflammation by modulating signaling pathways and inflammatory mediators. Thus, it is believed that these compounds are able to suppress chronic inflammation that characterizes many diseases like inflammatory bowel diseases. Inflammatory bowel diseases are characterized by chronic intestinal inflammation, intermittent episodes of clinical remission and relapse and are relatively common in developed countries. According to some studies, some polyphenols have the ability to inhibit molecules from signaling cascades in intestinal cell models. Furthermore, some clinical trials also suggest that these phenolic compounds decrease the number of relapses in ulcerative colitis patients and improve intestinal lesions in in vivo studies. This review addresses some facts about polyphenols, their potential as modulator of signaling cascades and their promising future as adjunctive therapy in patients with inflammatory bowel diseases.
Descrição
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2013
Palavras-chave
Polifenóis Inflamação Cascatas de sinalização Doenças Inflamatórias do Intestino Imunidade intestinal Mestrado Integrado - 2013