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Variation in type of adjuvant chemotherapy received among patients with stage I breast cancer: a multi-institutional Portuguese cohort study

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dc.contributor.authorFerreira, Arlindo
dc.contributor.authorPalha, Ana
dc.contributor.authorCorreia, Lurdes
dc.contributor.authorFilipe, Pedro
dc.contributor.authorRodrigues, Vasco
dc.contributor.authorCosta, Luis
dc.contributor.authorMiranda, Ana
dc.contributor.authorAndré, Rosário
dc.contributor.authorFernandes, João
dc.contributor.authorGouveia, Joaquim
dc.contributor.authorPassos-Coelho, José Luís
dc.contributor.authorMoreira, António
dc.contributor.authorBrito, Margarida
dc.contributor.authorRibeiro, Joana
dc.contributor.authorMetzger-Filho, Otto
dc.contributor.authorU. Lin, Nancy
dc.contributor.authorVaz-Luís, Inês
dc.date.accessioned2022-02-22T16:24:33Z
dc.date.available2022-02-22T16:24:33Z
dc.date.issued2016
dc.description© 2016 Elsevier Ltd. All rights reserved.pt_PT
dc.description.abstractBackground: A contemporary US study showed an increase in the use of chemotherapy in the last decade for some patients with stage-I breast cancer; with a rise in more intensive regimens, and declining use of anthracyclines. Nevertheless, there is still uncertainty on the absolute benefit of chemotherapy for these patients and the optimal regimen. In this study we compare those findings with the patterns of care among a Portuguese cohort of stage-I breast cancers. Methods: Retrospective cohort study of patients with stage-I breast cancer diagnosed from 2006 to 2008 at four Portuguese institutions. The use and type of chemotherapy was evaluated. Results: Among patients with stage I-III breast cancer 39.4% (n = 682) had stage I disease. Of the 595 eligible patients, 22.4% were treated with chemotherapy, 33.9% aged <55 years vs. 12.7% aged >65 years (p < 0.001). Thirteen percent of patients with hormone receptor (HR)+/HER2- tumors, 52.7% of patients with HER2+ and 66.0% of patients with HR-/HER2- received chemotherapy (p < 0.001). In addition, we found inter-institutional variability, with the use of chemotherapy ranging from 0.0% to 43.4% (p < 0.001). Eighty-five percent of patients treated with chemotherapy received less-intensive regimens with anthracycline-based regimens, such as doxorubicin and cyclophosphamide, being the most frequently used, while docetaxel and cyclophosphamide was only used in 1.5% of cases. Conclusions: Overall, almost one-quarter of patients received chemotherapy with institutional variability. When treated, mostly less-intensive associations including anthracyclines were used, which contrasts with contemporary US practice. This study highlights the need for health-services research to understand local practices and tailor quality improvement interventions.pt_PT
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT) grants HMSP-ICS/0004/201 to IVL and HMSP-ICJ/0007/2013 to ARF.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationThe Breast 29 (2016) 68-73pt_PT
dc.identifier.doi10.1016/j.breast.2016.07.004pt_PT
dc.identifier.eissn1532-3080
dc.identifier.issn0960-9776
dc.identifier.urihttp://hdl.handle.net/10451/51456
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationRelative effectivity of aromatase inhibitors versus tamoxifen in patients with early breast cancer
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/the-breastpt_PT
dc.subjectBreast cancerpt_PT
dc.subjectChemotherapypt_PT
dc.subjectStage Ipt_PT
dc.titleVariation in type of adjuvant chemotherapy received among patients with stage I breast cancer: a multi-institutional Portuguese cohort studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleRelative effectivity of aromatase inhibitors versus tamoxifen in patients with early breast cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/HMSP-ICS%2F0004%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/HMSP-ICJ%2F0007%2F2013/PT
oaire.citation.endPage73pt_PT
oaire.citation.startPage68pt_PT
oaire.citation.titleThe Breastpt_PT
oaire.citation.volume29pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
person.familyNameFerreira
person.familyNameCosta
person.givenNameArlindo
person.givenNameLuis
person.identifier.ciencia-idF112-254C-6DC4
person.identifier.ciencia-id041E-4ADE-FB64
person.identifier.orcid0000-0002-1567-9322
person.identifier.orcid0000-0002-4782-7318
person.identifier.scopus-author-id56707990400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication8a2ab4c6-ba86-4433-b4b7-6256d81890e5
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