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Bringing macrophages to the frontline against cancer: current Immunotherapies targeting macrophages

2021Artigo científico Acesso aberto
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dc.contributor.authorReis-Sobreiro, Mariana
dc.contributor.authorTeixeira da Mota, Afonso
dc.contributor.authorJardim, Carolina
dc.contributor.authorSerre, Karine
dc.date.accessioned2021-10-12T14:07:21Z
dc.date.available2021-10-12T14:07:21Z
dc.date.issued2021
dc.description© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractMacrophages are found in all tissues and display outstanding functional diversity. From embryo to birth and throughout adult life, they play critical roles in development, homeostasis, tissue repair, immunity, and, importantly, in the control of cancer growth. In this review, we will briefly detail the multi-functional, protumoral, and antitumoral roles of macrophages in the tumor microenvironment. Our objective is to focus on the ever-growing therapeutic opportunities, with promising preclinical and clinical results developed in recent years, to modulate the contribution of macrophages in oncologic diseases. While the majority of cancer immunotherapies target T cells, we believe that macrophages have a promising therapeutic potential as tumoricidal effectors and in mobilizing their surroundings towards antitumor immunity to efficiently limit cancer progression.pt_PT
dc.description.sponsorshipThis work was supported by an iMM-Laço research grant and the Fundacão para a Ciência e Tecnologia through a research grant (PTDC/MED-IMU/30948/2017) and a personal fellowship (CEECIND/00697/2018) received by K.S. and a PhD fellowship (SFRH/BD/144792/2019) to C.J. This work was also kindly backed by the COST Action BM1404 Mye-EUNITER (http://www.mye-euniter.eu accessed on 26 November 2018). COST is supported by the EU Framework Program Horizon 2020.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCells. 2021 Sep 9;10(9):2364pt_PT
dc.identifier.doi10.3390/cells10092364pt_PT
dc.identifier.eissn2073-4409
dc.identifier.urihttp://hdl.handle.net/10451/49865
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/journal/cellspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntitumor functionspt_PT
dc.subjectMacrophagespt_PT
dc.subjectMyeloid-targeted therapiespt_PT
dc.subjectReprogrammingpt_PT
dc.titleBringing macrophages to the frontline against cancer: current Immunotherapies targeting macrophagespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/152174/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/6764/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/74699/PT
oaire.citation.issue9pt_PT
oaire.citation.titleCellspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamCEEC IND 2018
oaire.fundingStreamOE
person.familyNameReis Sobreiro
person.familyNameCarreira Gomes Jardim
person.familyNameSerre
person.givenNameMariana
person.givenNameCarolina Emanuel
person.givenNameKarine
person.identifierhttps://scholar.google.com/citations?user=PWfEE0QAAAAJ&hl=pt-BR&oi=sra
person.identifier120366
person.identifier.ciencia-idD111-9AA5-1E27
person.identifier.ciencia-id2115-AAB3-4424
person.identifier.ciencia-id1E11-7283-DF35
person.identifier.orcid0000-0003-0286-0824
person.identifier.orcid0000-0001-6929-6469
person.identifier.orcid0000-0001-9152-4739
person.identifier.scopus-author-id6602493849
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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