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The power of dying slowly - persistence as unintentional dormancy

2021-01-20Journal article Open access
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dc.contributor.authorRebelo, João S.
dc.contributor.authorDomingues, Célia P. F.
dc.contributor.authorMonteiro, Francisca
dc.contributor.authorNogueira, Teresa
dc.contributor.authorDionisio, Francisco
dc.date.accessioned2021-04-22T19:27:43Z
dc.date.available2021-04-22T19:27:43Z
dc.date.issued2021-01-20
dc.description.abstractPersistence is a state of bacterial dormancy where cells with low metabolic activity and growth rates are phenotypically tolerant to antibiotics and other cytotoxic substances. Given its obvious advantage to bacteria, several researchers have been looking for the genetic mechanism behind persistence. However, other authors argue that there is no such mechanism and that persistence results from inadvertent cell errors. In this case, the persistent population should decay according to a power-law with a particular exponent of −2. Studying persisters’ decay is, therefore, a valuable way to understand persistence. Here we simulated the fate of susceptible cells in laboratory experiments in the context of indirect resistance. Eventually, under indirect resistance, detoxifying drug-resistant cells save the persister cells that leave the dormant state and resume growth. The simulations presented here show that, by assuming a power-law decline, the exponent is close to −2, which is the expected value if persistence results from unintentional errors. Whether persisters are cells in a moribund state or, on the contrary, result from a genetic program, should impact the research of anti-persistent drugs.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1101/2021.01.20.427471pt_PT
dc.identifier.urihttp://hdl.handle.net/10451/47528
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.publisherBioRxivpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/pt_PT
dc.subjectPersistence; power-law; exponential decay; indirect resistance; indirect pathogenicity; antibiotic resistance; beta-lactamase; beta-lactais; ampicillinpt_PT
dc.titleThe power of dying slowly - persistence as unintentional dormancypt_PT
dc.typejournal article
dspace.entity.typePublication
person.familyNameRebelo
person.familyNameDomingues
person.familyNameSarreira Simões Horta Monteiro
person.familyNameVitorino Nogueira
person.familyNameDionísio
person.givenNameJoão
person.givenNameCélia
person.givenNameFrancisca
person.givenNameTeresa Isabel
person.givenNameFrancisco
person.identifierG-2273-2010
person.identifierA-2129-2009
person.identifier.ciencia-idA015-FF75-397C
person.identifier.ciencia-id3416-6299-1379
person.identifier.ciencia-idA815-CE3A-53C9
person.identifier.ciencia-idF211-4E18-2C69
person.identifier.ciencia-id7413-DB46-16E0
person.identifier.orcid0000-0002-8662-7378
person.identifier.orcid0000-0003-2970-010X
person.identifier.orcid0000-0002-5275-714X
person.identifier.orcid0000-0002-0059-5177
person.identifier.orcid0000-0002-3653-1511
person.identifier.scopus-author-id7004351448
person.identifier.scopus-author-id6506790127
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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