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Effect of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, and associated metabolic comorbidities: a systematic review

2024Journal article Open access
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dc.contributor.authorCespiati, Annalisa
dc.contributor.authorRodrigues, Inês Coelho
dc.contributor.authorSantos, Inês
dc.contributor.authorPolicarpo, Sara
dc.contributor.authorCarvalhana, Sofia
dc.contributor.authorFracanzani, Anna Ludovica
dc.contributor.authorCortez-Pinto, Helena
dc.date.accessioned2024-05-03T14:50:33Z
dc.date.available2024-05-03T14:50:33Z
dc.date.issued2024
dc.description© 2024 The Authors. Liver International published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.pt_PT
dc.description.abstractBackground and Aims The beneficial effect of Hepatitis C virus (HCV) eradication by direct antiviral agents (DAAs) on liver fibrosis is well defined. Despite this, the impact of viral eradication in both hepatic and extra-hepatic metabolic features is underreached. This systematic review aimed to synthesize the evidence on the impact of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, glucidic impairment, dyslipidaemia, and weight gain. Methods A systematic search of the existing literature (up to December 2022) identified 97 original studies that fulfilled the inclusion criteria. Results Whereas total cholesterol and low-density lipoprotein (LDL) seem to increase after viral eradication, the cardiovascular damage expressed as carotid plaques and intima-media thickness seems to improve. Otherwise, the effect on liver steatosis, glucidic homeostasis, and weight seems to be strictly dependent on the presence of baseline metabolic disorders. Conclusion Despite high heterogeneity and relatively short follow-up of included studies, we can conclude that the presence of metabolic risk factors should be strictly evaluated due to their impact on liver steatosis, glucidic and lipid homeostasis, and on weight gain to better identify patients at risk of liver disease progression despite the virus eradication.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLiver Int. 2024 May;44(5):1075-1092pt_PT
dc.identifier.doi10.1111/liv.15876pt_PT
dc.identifier.eissn1478-3231
dc.identifier.issn1478-3223
dc.identifier.urihttp://hdl.handle.net/10451/64667
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/14783231pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBody weightpt_PT
dc.subjectCarotid atherosclerosispt_PT
dc.subjectDiabetes mellituspt_PT
dc.subjectDyslipidaemiapt_PT
dc.subjectFatty liverpt_PT
dc.subjectHepatitis C viruspt_PT
dc.titleEffect of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, and associated metabolic comorbidities: a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1092pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage1075pt_PT
oaire.citation.titleLiver Internationalpt_PT
oaire.citation.volume44pt_PT
person.familyNameChaparro Roque dos Santos
person.familyNamePolicarpo
person.familyNamecarvalhana
person.familyNameCortez-Pinto
person.givenNameInês
person.givenNameSara
person.givenNamesofia
person.givenNameHelena
person.identifierN-1856-2016
person.identifier.ciencia-id8E14-4B1D-9F4E
person.identifier.ciencia-idA01C-0511-C986
person.identifier.orcid0000-0002-1638-8551
person.identifier.orcid0000-0001-8594-1720
person.identifier.orcid0000-0001-6120-2333
person.identifier.orcid0000-0002-8537-8744
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication6e672e07-deab-42de-ac5a-8d91cd617873
relation.isAuthorOfPublication18ef9bc3-1f7a-414b-b2aa-a1163f2f2367
relation.isAuthorOfPublicationcb236618-84cf-4c42-a22f-3d6d0521e768
relation.isAuthorOfPublication91fdb4b3-d491-4e67-94ff-dcf5013fa1a7
relation.isAuthorOfPublication.latestForDiscovery6e672e07-deab-42de-ac5a-8d91cd617873

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