Repository logo
 
Publication

The GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy

2018Journal article Open access
Simple item page
dc.contributor.authorVieira de Sousa, Elsa Cristina
dc.contributor.authorCanhao, Helena
dc.contributor.authorAlves, Pedro
dc.contributor.authorRodrigues, Ana Maria
dc.contributor.authorTeixeira, Filipa
dc.contributor.authorTavares-Costa, José
dc.contributor.authorBernardo, Alexandra
dc.contributor.authorPimenta, Sofia
dc.contributor.authorPimentel-Santos, Fernando
dc.contributor.authorGomes, João L
dc.contributor.authorAguiar, Renata
dc.contributor.authorVideira, Taciana
dc.contributor.authorPinto, Patrícia
dc.contributor.authorCatita, Cristina
dc.contributor.authorSantos, Helena
dc.contributor.authorBorges, Joana
dc.contributor.authorSequeira, Graça
dc.contributor.authorRibeiro, Célia
dc.contributor.authorTeixeira, Lídia
dc.contributor.authorÁvila-Ribeiro, Pedro
dc.contributor.authorMartins, Fernando M
dc.contributor.authorRibeiro, Ruy M.
dc.contributor.authorFonseca, João Eurico
dc.date.accessioned2020-12-03T18:00:56Z
dc.date.available2020-12-03T18:00:56Z
dc.date.issued2018
dc.description© 2001-2020 Sociedade Portuguesa de Reumatologiapt_PT
dc.description.abstractThe GO-DACT is an investigator-initiated, national, multicentric randomized placebo-controlled double-blinded trial, that assesses dactylitis as primary endpoint. Psoriatic arthritis patients naïve to methotrexate and biologic disease modifying anti-rheumatic drugs, with at least one active dactylitis, were assigned to golimumab in combination with methotrexate or placebo in combination with methotrexate, for 24 weeks. Both clinical (dactylitis severity score and the Leeds dactylitis index) and imaging (high resolution magnetic resonance imaging), among others, were assessed as outcomes. The main objective of GO-DACT is to provide evidence to improve the treatment algorithm and care of psoriatic arthritis patients with active dactylitis. In this manuscript we describe the GO-DACT protocol and general concepts of the methodology of this trial.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationActa Reumatol Port. 2018 Apr-Jun; 43 (2): 80-92pt_PT
dc.identifier.issn0303-464X
dc.identifier.urihttp://hdl.handle.net/10451/45121
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Portuguesa de Reumatologiapt_PT
dc.relation.publisherversionhttp://www.actareumatologica.pt/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectClinical trialpt_PT
dc.subjectDactylitispt_PT
dc.subjectTreatment algorithmpt_PT
dc.subjectPsoriatic arthritispt_PT
dc.titleThe GO-DACT protocol : a multicentre, randomized, double-blind, parallel-group study to compare the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage82pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage80pt_PT
oaire.citation.titleActa Reumatológica Portuguesapt_PT
oaire.citation.volume43pt_PT
person.familyNameVieira de Sousa
person.familyNameCanhao
person.familyNameRibeiro
person.familyNameFonseca
person.givenNameElsa Cristina
person.givenNameHelena
person.givenNameRuy Miguel
person.givenNameJoão
person.identifier.ciencia-id1519-509A-8B89
person.identifier.ciencia-id9A15-E40B-738F
person.identifier.ciencia-idF310-B85D-57C7
person.identifier.orcid0000-0002-7170-8802
person.identifier.orcid0000-0002-3239-2809
person.identifier.orcid0000-0002-3988-8241
person.identifier.orcid0000-0003-1432-3671
person.identifier.scopus-author-id6602393492
person.identifier.scopus-author-id7101983519
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8b9873ad-2667-48e6-aece-a73dec6a8296
relation.isAuthorOfPublication48f3be39-37f9-44de-9c7e-22e49a89efe5
relation.isAuthorOfPublication215b5cf4-faab-41ea-becf-c63bed56d3d1
relation.isAuthorOfPublication1772dc12-7c55-4c76-ae2d-c23270172480
relation.isAuthorOfPublication.latestForDiscovery48f3be39-37f9-44de-9c7e-22e49a89efe5

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
GO-DACT_protocol.pdf
Size:
4.09 MB
Format:
Adobe Portable Document Format
Download

Collections

FM-IMPSP-Artigos em Revistas Nacionais
FM-CUR-Artigos em Revistas Nacionais
IMM - Artigos em Revistas Nacionais