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A critique of the fragility index

dc.contributor.authorMachado, Tiago
dc.contributor.authorDuarte, Gonçalo Silva
dc.contributor.authorGonçalves, Nilza C.
dc.contributor.authorFerreira, Joaquim J.
dc.contributor.authorCosta, João
dc.date.accessioned2019-10-23T11:14:48Z
dc.date.available2019-10-23T11:14:48Z
dc.date.issued2019-10
dc.descriptionCopyright © 2019 Elsevier B.V. or its licensors or contributors.pt_PT
dc.description.abstractIn The Lancet Oncology , Joseph Del Paggio and Ian Tannock report on a retrospective analysis of the fragility indices of phase 3 trials used by the US Food and Drug Administration (FDA) to approve anticancer drugs. 1 The authors conclude that “many phase 3 randomised controlled trials supporting FDA-approved anticancer drugs have a low fragility index, challenging confidence for concluding their superiority over control treatments.” Although this interpretation is interesting, we would like to draw attention to several points.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLancet Oncol. 2019 Oct;20(10):e553pt_PT
dc.identifier.doi10.1016/S1470-2045(19)30581-9.
dc.identifier.issn1470-2045
dc.identifier.urihttp://hdl.handle.net/10451/39924
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.thelancet.com/journals/lanonc/issue/currentpt_PT
dc.titleA critique of the fragility indexpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPagee553pt_PT
oaire.citation.titleLancet Oncologypt_PT
person.familyNameDuarte
person.familyNameFerreira
person.familyNameCosta
person.givenNameGonçalo
person.givenNameJoaquim J
person.givenNameJoão
person.identifier1624753
person.identifier480560
person.identifier.ciencia-id7D15-5CD6-6159
person.identifier.orcid0000-0001-7802-1897
person.identifier.orcid0000-0003-3950-5113
person.identifier.orcid0000-0002-5831-4921
person.identifier.ridL-4920-2015
person.identifier.scopus-author-id7403252466
person.identifier.scopus-author-id55499748300
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication06baa442-3f09-4ee2-b0ee-cf3036a26afd
relation.isAuthorOfPublication54d84fe7-2cbd-4ddc-bce2-0ff2bd7c4cc9
relation.isAuthorOfPublication0924f405-2d3a-4914-9097-24aa639bd97f
relation.isAuthorOfPublication.latestForDiscovery06baa442-3f09-4ee2-b0ee-cf3036a26afd

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