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Arginine and arginases modulate metabolism, tumor microenvironment and prostate cancer progression

2021Artigo científico Acesso aberto
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dc.contributor.authorMatos, Andreia
dc.contributor.authorCarvalho, Marcos
dc.contributor.authorBicho, Manuel
dc.contributor.authorRibeiro, Ricardo
dc.date.accessioned2022-01-07T17:00:42Z
dc.date.available2022-01-07T17:00:42Z
dc.date.issued2021
dc.description© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractArginine availability and activation of arginine-related pathways at cancer sites have profound effects on the tumor microenvironment, far beyond their well-known role in the hepatic urea cycle. Arginine metabolism impacts not only malignant cells but also the surrounding immune cells behavior, modulating growth, survival, and immunosurveillance mechanisms, either through an arginase-mediated effect on polyamines and proline synthesis, or by the arginine/nitric oxide pathway in tumor cells, antitumor T-cells, myeloid-derived suppressor cells, and macrophages. This review presents evidence concerning the impact of arginine metabolism and arginase activity in the prostate cancer microenvironment, highlighting the recent advances in immunotherapy, which might be relevant for prostate cancer. Even though further research is required, arginine deprivation may represent a novel antimetabolite strategy for the treatment of arginine-dependent prostate cancer.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNutrients. 2021 Dec 16;13(12):4503pt_PT
dc.identifier.doi10.3390/nu13124503pt_PT
dc.identifier.eissn2072-6643
dc.identifier.urihttp://hdl.handle.net/10451/50748
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/journal/nutrientspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectArginasept_PT
dc.subjectArgininept_PT
dc.subjectMetabolismpt_PT
dc.subjectNitric oxidept_PT
dc.subjectProstate cancerpt_PT
dc.subjectTumor microenvironmentpt_PT
dc.titleArginine and arginases modulate metabolism, tumor microenvironment and prostate cancer progressionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue12pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume13pt_PT
person.familyNameMatos
person.familyNameBicho
person.familyNameTeixeira Ribeiro
person.givenNameAndreia
person.givenNameManuel
person.givenNameRicardo Jorge
person.identifier420846
person.identifier.ciencia-idDD1F-390C-A468
person.identifier.ciencia-id9512-8D22-1B28
person.identifier.ciencia-id8612-04D5-18B9
person.identifier.orcid0000-0003-1551-9465
person.identifier.orcid0000-0002-5773-5687
person.identifier.orcid0000-0001-9785-857X
person.identifier.scopus-author-id7004153755
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication134accf1-1d8c-4a6d-8716-10b13c304505
relation.isAuthorOfPublicationc61e4f7e-28b3-47b4-bc5d-677b73fc3aec
relation.isAuthorOfPublicationa746f267-3647-4845-adbe-b0af2daee5db
relation.isAuthorOfPublication.latestForDiscoveryc61e4f7e-28b3-47b4-bc5d-677b73fc3aec

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