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Publication
The mammary gland in domestic ruminants : a systems biology perspective
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Advisor(s)
Abstract(s)
Milk and dairy products are central elements in the human diet. It is estimated that 108 kg
of milk per year are consumed per person worldwide. Therefore, dairy production
represents a relevant fraction of the economies of many countries, being cattle, sheep,
goat, water buffalo, and other ruminants the main species used worldwide. An adequate
management of dairy farming cannot be achieved without the knowledge on the biological
mechanisms behind lactation in ruminants. Thus, understanding the morphology,
development and regulation of the mammary gland in health, disease and production is
crucial. Presently, innovative and high-throughput technologies such as genomics,
transcriptomics, proteomics and metabolomics allow a much broader and detailed
knowledge on such issues. Additionally, the application of a systems biology approach to
animal science is vastly growing, as new advances in one field of specialization or animal
species lead to new lines of research in other areas or/and are expanded to other species.
This article addresses how modern research approaches may help us understand
long-known issues in mammary development, lactation biology and dairy production.
Biological significance
Dairy production depends upon the knowledge of the morphology and regulation of the
mammary gland and lactation. High-throughput technologies allow a much broader and
detailed knowledge on the biology of the mammary gland. This paper reviews the major
contributions that genomics, transcriptomics, metabolomics and proteomics approaches
have provided to understand the regulation of the mammary gland in health, disease and
production. In the context of mammary gland “omics”-based research, the integration of
results using a Systems Biology Approach is of key importance.
Description
Articles in International Journals
Keywords
Mammary gland Lactation Mastitis Dairy production Ruminants “Omics”
Pedagogical Context
Citation
Ferreira, A.M., Bislevc, S.L., Bendixenc, E., Almeida, A.M. (2013). The mammary gland in domestic ruminants : a systems biology perspective. Journal of Proteomics, 9(4), 110-123. doi: 10.1016/j.jprot.2013.09.012
Publisher
Elsevier B.V.