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Accidental father-to-son HIV-1 transmission during the seroconversion period

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dc.contributor.authorEzeonwumelu, Ifeanyi J.
dc.contributor.authorBártolo, Inês
dc.contributor.authorMartin, Francisco
dc.contributor.authorAbecasis, Ana B.
dc.contributor.authorCampos, Teresa
dc.contributor.authorRomero-Severson, Ethan
dc.contributor.authorLeitner, Thomas
dc.contributor.authorTaveira, Nuno
dc.date.accessioned2023-08-23T17:03:52Z
dc.date.available2023-08-23T17:03:52Z
dc.date.issued2018
dc.date.updated2023-02-03T14:15:36Z
dc.description.abstractA 4-year-old child born to an HIV-1 seronegative mother was diagnosed with HIV-1, the main risk factor being transmission from the child's father who was seroconverting at the time of the child's birth. In the context of a forensic investigation, we aimed to identify the source of infection of the child and date of the transmission event. Samples were collected from the father and child at two time points about 4 years after the child's birth. Partial segments of three HIV-1 genes (gag, pol, and env) were sequenced and maximum likelihood (ML) and Bayesian methods were used to determine direction and estimate date of transmission. Neutralizing antibodies were determined using a single cycle assay. Bayesian trees displayed a paraphyletic–monophyletic topology in all three genomic regions, with the father's host label at the root, which is consistent with father-to-son transmission. ML trees found similar topologies in gag and pol and a monophyletic–monophyletic topology in env. Analysis of the time of the most recent common ancestor of each HIV-1 gene population indicated that the child was infected shortly after the father. Consistent with the infection history, both father and son developed broad and potent HIV-specific neutralizing antibody responses. In conclusion, the direction of transmission implicated the father as the source of transmission. Transmission occurred during the seroconversion period when the father was unaware of the infection and was likely accidental. This case shows how genetic, phylogenetic, and serological data can contribute for the forensic investigation of HIV transmission.pt_PT
dc.description.sponsorshipResearch reported in this publication was supported by the NIAID/NIH under award number R01AI087520, by European Funds through grant ‘Bio-Molecular and Epidemiological Surveillance of HIV Transmitted Drug Resistance, Hepatitis Coinfections and Ongoing Transmission Patterns in Europe (BEST HOPE) (project funded through HIVERA: Harmonizing Integrating Vitalizing European Research on HIV/Aids, grant 249697) and by grants PTDC/SAU-EPI/122400/2010, VIH/SAU/0029/2011, and PTDC/DTP-EPI/7066/2014 from Fundação para a Ciência e Tecnologia (FCT), Portugal. Global Health and Tropical Medicine Center was funded through FCT (UID/Multi/04413/2013). Inês Bártolo was supported by a postdoc fellowship (SFRH/BPD/76225/2011) from FCT, Portugal. A.A. was supported by Fundação para a Ciência e Tecnologia (FCT) through Investigador FCT Program.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEzeonwumelu I, Bártolo I, Martin F, Abecasis A, Campos T, Romero-Severson EO, et al. Accidental father-to-son hiv-1 transmission during the seroconversion period. AIDS Research and Human Retroviruses [Internet]. outubro de 2018;34(10):857–62. Disponível em: https://www.liebertpub.com/doi/full/10.1089/aid.2018.0060pt_PT
dc.identifier.doi10.1089/aid.2018.0060pt_PT
dc.identifier.eid2-s2.0-85055074618
dc.identifier.slugcv-prod-1108453
dc.identifier.urihttp://hdl.handle.net/10451/58976
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMary Ann Liebert, Inc.pt_PT
dc.relationHarmonizing, Integrating and Vitalizing European Research on hiv/Aids
dc.relationMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
dc.relationGlobal Health and Tropical Medicine
dc.relationDESENVOLVIMENTO DE NOVOS MICROBICIDAS PARA PREVENIR A INFECÇÃO POR VIH
dc.relation.publisherversionhttps://www.liebertpub.com/doi/full/10.1089/aid.2018.0060pt_PT
dc.titleAccidental father-to-son HIV-1 transmission during the seroconversion periodpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHarmonizing, Integrating and Vitalizing European Research on hiv/Aids
oaire.awardTitleMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
oaire.awardTitleGlobal Health and Tropical Medicine
oaire.awardTitleDESENVOLVIMENTO DE NOVOS MICROBICIDAS PARA PREVENIR A INFECÇÃO POR VIH
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/249697/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-EPI%2F122400%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/VIH%2FSAU%2F0029%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-EPI%2F7066%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04413%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F76225%2F2011/PT
oaire.citation.endPage862pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage857pt_PT
oaire.citation.titleAIDS Research and Human Retrovirusespt_PT
oaire.citation.volume34pt_PT
oaire.fundingStreamFP7
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
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project.funder.identifierhttp://doi.org/10.13039/501100008530
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid661E-F5CB-F85A | Inês Bártolo
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