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Presence and persistence of the amnesic shellfish poisoning toxin, domoic acid, in octopus and cuttlefish brains

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dc.contributor.authorLopes, Vanessa M.
dc.contributor.authorRosa, Rui
dc.contributor.authorCosta, Pedro R.
dc.date.accessioned2020-01-19T21:08:12Z
dc.date.available2020-01-19T21:08:12Z
dc.date.issued2018
dc.description.abstractDomoic acid (DA) is a neurotoxin that causes degenerative damage to brain cells and induces permanent short-term memory loss in mammals. In cephalopod mollusks, although DA is known to accumulate primarily in the digestive gland, there is no knowledge whether DA reaches their central nervous system. Here we report, for the first time, the presence of DA in brain tissue of the common octopus (Octopus vulgaris) and the European cuttlefish (Sepia officinalis), and its absence in the brains of several squid species (Loligo vulgaris, L. forbesi and Todarodes sagittatus). We argue that such species-specific differences are related to their different life strategies (benthic/nektobenthic vs pelagic) and feeding ecologies, as squids mainly feed on pelagic fish, which are less prone to accumulate phycotoxins. Additionally, the temporal persistence of DA in octopus' brain reinforces the notion that these invertebrates can selectively retain this phycotoxin. This study shows that two highly-developed invertebrate species, with a complex central nervous system, where glutamatergic transmission is involved in vertebrate-like long-term potentiation (LTP), have the ability of retaining and possibly tolerating chronic exposure to DA, a potent neurotoxin usually acting at AMPA/kainate-like receptors. Here, we filled a gap of information on whether cephalopods accumulated this neurotoxin in brain tissue, however, further studies are needed to determine if these organisms are neurally or behaviourally impaired by DA.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.marenvres.2017.12.001pt_PT
dc.identifier.issn0141-1136
dc.identifier.urihttp://hdl.handle.net/10451/41240
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0141113617304397pt_PT
dc.subjectDomoic acidpt_PT
dc.subjectBrainpt_PT
dc.subjectCephalopodpt_PT
dc.subjectOctopuspt_PT
dc.subjectCuttlefishpt_PT
dc.subjectBioaccumulationpt_PT
dc.subjectAlgal toxinspt_PT
dc.subjectToxicitypt_PT
dc.titlePresence and persistence of the amnesic shellfish poisoning toxin, domoic acid, in octopus and cuttlefish brainspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage48pt_PT
oaire.citation.startPage45pt_PT
oaire.citation.titleMarine Environmental Researchpt_PT
oaire.citation.volume133pt_PT
person.familyNameLopes
person.familyNameRosa
person.givenNameVanessa
person.givenNameRui
person.identifier430759
person.identifier.ciencia-id151A-5D01-363A
person.identifier.ciencia-id2B10-7D61-FF7A
person.identifier.orcid0000-0001-8276-4490
person.identifier.orcid0000-0003-2801-5178
person.identifier.ridH-3232-2014
person.identifier.ridA-4580-2009
person.identifier.scopus-author-id7102610088
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication27211b8b-2525-46fc-80a8-557283a919ab
relation.isAuthorOfPublication395f77c0-ac42-4b7c-9b4a-07fdb75305cc
relation.isAuthorOfPublication.latestForDiscovery395f77c0-ac42-4b7c-9b4a-07fdb75305cc

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