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Overexpression of Adenosine A2A receptors in rats: effects on depression, locomotion, and anxiety

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dc.contributor.authorCoelho, Joana E
dc.contributor.authorAlves, Pedro Nascimento
dc.contributor.authorCanas, Paula M.
dc.contributor.authorValadas, Jorge S.
dc.contributor.authorShmidt, Tatiana
dc.contributor.authorBatalha, Vânia
dc.contributor.authorFerreira, Diana G.
dc.contributor.authorRibeiro, Joaquim A.
dc.contributor.authorBader, Michael
dc.contributor.authorCunha, Rodrigo A.
dc.contributor.authorSimões Do Couto, Frederico
dc.contributor.authorLopes, Luisa V.
dc.date.accessioned2022-02-10T17:04:57Z
dc.date.available2022-02-10T17:04:57Z
dc.date.issued2014
dc.descriptionCopyright: © 2014 Coelho, Alves, Canas, Valadas, Shmidt, Batalha, Ferreira, Ribeiro, Bader, Cunha, do Couto and Lopes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractAdenosine A2A receptors (A2AR) are a sub-type of receptors enriched in basal ganglia, activated by the neuromodulator adenosine, which interact with dopamine D2 receptors. Although this reciprocal antagonistic interaction is well-established in motor function, the outcome in dopamine-related behaviors remains uncertain, in particular in depression and anxiety. We have demonstrated an upsurge of A2AR associated to aging and chronic stress. Furthermore, Alzheimer's disease patients present A2AR accumulation in cortical areas together with depressive signs. We now tested the impact of overexpressing A2AR in forebrain neurons on dopamine-related behavior, namely depression. Adult male rats overexpressing human A2AR under the control of CaMKII promoter [Tg(CaMKII-hA2AR)] and aged-matched wild-types (WT) of the same strain (Sprague-Dawley) were studied. The forced swimming test (FST), sucrose preference test (SPT), and the open-field test (OFT) were performed to evaluate behavioral despair, anhedonia, locomotion, and anxiety. Tg(CaMKII-hA2AR) animals spent more time floating and less time swimming in the FST and presented a decreased sucrose preference at 48 h in the SPT. They also covered higher distances in the OFT and spent more time in the central zone than the WT. The results indicate that Tg(CaMKII-hA2AR) rats exhibit depressive-like behavior, hyperlocomotion, and altered exploratory behavior. This A2AR overexpression may explain the depressive signs found in aging, chronic stress, and Alzheimer's disease.pt_PT
dc.description.sponsorshipJoana E. Coelho, Vânia L. Batalha and Diana G. Ferreira were supported by a grant from Fundação para a Ciência e Tecnologia (FCT); Paula M. Canas and Rodrigo A. Cunha were supported by FCT (PTDC/SAU-NSC/122254/2010) and Defense Advanced Research Projects Agency (DARPA, grant 09-68-ESR- FP-010). Luísa V. Lopes is an Investigator FCT, funded by Fundação para a Ciência e Tecnologia (PTDC-099853/2009) and Bial.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Psychiatry. 2014 Jun 13;5:67pt_PT
dc.identifier.doi10.3389/fpsyt.2014.00067pt_PT
dc.identifier.eissn1664-0640
dc.identifier.urihttp://hdl.handle.net/10451/51216
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationPTDC-099853/2009pt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/journals/psychiatry#pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAdenosine A2A receptorspt_PT
dc.subjectAnxietypt_PT
dc.subjectDepressionpt_PT
dc.subjectDopaminept_PT
dc.subjectLocomotionpt_PT
dc.subjectMemorypt_PT
dc.subjectStresspt_PT
dc.titleOverexpression of Adenosine A2A receptors in rats: effects on depression, locomotion, and anxietypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPTDC/SAU-NSC/122254/2010
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FSAU-NSC%2F122254%2F2010/PT
oaire.citation.titleFrontiers in Psychiatrypt_PT
oaire.citation.volume5pt_PT
oaire.fundingStreamCOMPETE
person.familyNameCoelho
person.familyNameNascimento Alves
person.familyNameValadas
person.familyNameBatalha
person.familyNameRibeiro
person.familyNameSimões do Couto
person.familyNameLopes
person.givenNameJoana
person.givenNamePedro
person.givenNameJorge S.
person.givenNameVânia
person.givenNameJoaquim
person.givenNameFrederico
person.givenNameLuisa
person.identifier149432
person.identifier.ciencia-idB310-839B-564D
person.identifier.ciencia-id561D-EA98-5D64
person.identifier.ciencia-idA915-3406-B4D3
person.identifier.ciencia-id081F-2518-907F
person.identifier.ciencia-idD117-0296-8086
person.identifier.ciencia-id4817-7194-C024
person.identifier.orcid0000-0002-3964-6197
person.identifier.orcid0000-0001-5740-5904
person.identifier.orcid0000-0002-2126-9485
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person.identifier.ridJ-9374-2017
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person.identifier.scopus-author-id35498669400
person.identifier.scopus-author-id14621494400
person.identifier.scopus-author-id7102509159
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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