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Cannabinoid actions on neural stem cells: implications for pathophysiology

2019-04-05Artigo científico Acesso aberto
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dc.contributor.authorRodrigues, Rui S.
dc.contributor.authorLourenço, Diogo M.
dc.contributor.authorPaulo, Sara L
dc.contributor.authorMateus, Joana
dc.contributor.authorFerreira, Miguel F.
dc.contributor.authorMouro, Francisco
dc.contributor.authorMoreira, João B.
dc.contributor.authorRibeiro, Filipa
dc.contributor.authorSebastião, Ana M
dc.contributor.authorXapelli, Sara
dc.date.accessioned2021-07-26T13:07:07Z
dc.date.available2021-07-26T13:07:07Z
dc.date.issued2019-04-05
dc.description© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractWith the increase of life expectancy, neurodegenerative disorders are becoming not only a health but also a social burden worldwide. However, due to the multitude of pathophysiological disease states, current treatments fail to meet the desired outcomes. Therefore, there is a need for new therapeutic strategies focusing on more integrated, personalized and effective approaches. The prospect of using neural stem cells (NSC) as regenerative therapies is very promising, however several issues still need to be addressed. In particular, the potential actions of pharmacological agents used to modulate NSC activity are highly relevant. With the ongoing discussion of cannabinoid usage for medical purposes and reports drawing attention to the effects of cannabinoids on NSC regulation, there is an enormous, and yet, uncovered potential for cannabinoids as treatment options for several neurological disorders, specifically when combined with stem cell therapy. In this manuscript, we review in detail how cannabinoids act as potent regulators of NSC biology and their potential to modulate several neurogenic features in the context of pathophysiology.pt_PT
dc.description.sponsorshipThis work was supported by IF/01227/2015 and UID/BIM/50005/2019, projeto financiado pela Fundação para a Ciência e a Tecnologia (FCT)/ Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) através de Fundos do Orçamento de Estado. R.S.R. (SFRH/BD/129710/2017), D.M.L. (PD/BD/141784/2018), F.F.R. (SFRH/BD/74662/2010), F.M.M. (IMM/CT/8-2018) were in receipt of a fellowship from FCT.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMolecules. 2019 Apr 5;24(7):1350pt_PT
dc.identifier.doi10.3390/molecules24071350pt_PT
dc.identifier.eissn1420-3049
dc.identifier.urihttp://hdl.handle.net/10451/49114
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationIMM/CT/8-2018pt_PT
dc.relationInstituto de Medicina Molecular
dc.relationCB2ExStress: a neurogenic strategy to tackle mood disorders
dc.relationA designar
dc.relationADENOSINE A2A RECEPTOR MODULATION OF NEURONAL MATURATION
dc.relation.publisherversionhttps://www.mdpi.com/journal/moleculespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCannabinoidspt_PT
dc.subjectNeural stem cellspt_PT
dc.subjectNeurogenesispt_PT
dc.subjectRegenerationpt_PT
dc.subjectPathophysiologypt_PT
dc.titleCannabinoid actions on neural stem cells: implications for pathophysiologypt_PT
dc.typejournal article
dspace.entity.typePublication
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oaire.awardTitleCB2ExStress: a neurogenic strategy to tackle mood disorders
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oaire.awardTitleADENOSINE A2A RECEPTOR MODULATION OF NEURONAL MATURATION
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oaire.citation.issue7pt_PT
oaire.citation.titleMolecules (Basel, Switzerland)pt_PT
oaire.citation.volume24pt_PT
oaire.fundingStreamInvestigador FCT
oaire.fundingStream6817 - DCRRNI ID
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