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Are Virulence and Antibiotic Resistance Genes Linked? A Comprehensive Analysis of Bacterial Chromosomes and Plasmids

2022-05-24Journal article Open access
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dc.contributor.authorDarmancier, Helena
dc.contributor.authorDomingues, Célia P. F.
dc.contributor.authorRebelo, João S.
dc.contributor.authorAmaro, Ana
dc.contributor.authorDionisio, Francisco
dc.contributor.authorPothier, Joel
dc.contributor.authorSerra, Octavio
dc.contributor.authorNogueira, Teresa
dc.date.accessioned2022-05-24T15:21:40Z
dc.date.available2022-05-24T15:21:40Z
dc.date.issued2022-05-24
dc.description.abstractAlthough pathogenic bacteria are the targets of antibiotics, these drugs also affect hundreds of commensal or mutualistic species. Moreover, the use of antibiotics is not only restricted to the treatment of infections but is also largely applied in agriculture and in prophylaxis. During this work, we tested the hypothesis that there is a correlation between the number and the genomic location of antibiotic resistance (AR) genes and virulence factor (VF) genes. We performed a comprehensive study of 16,632 reference bacterial genomes in which we identified and counted all orthologues of AR and VF genes in each of the locations: chromosomes, plasmids, or in both locations of the same genome. We found that, on a global scale, no correlation emerges. However, some categories of AR and VF genes co-occur preferentially, and in the mobilome, which supports the hypothesis that some bacterial pathogens are under selective pressure to be resistant to specific antibiotics, a fact that can jeopardize antimicrobial therapy for some human-threatening diseasespt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10451/53166
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationFCT PTDC/CVT-CVT/28469/2017pt_PT
dc.relationFCT PTDC/BIA-MIC/28824/2017pt_PT
dc.relationFCT UI/BD/153078/2022pt_PT
dc.relationFCT SFRH/BD/04631/2021pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectantibiotic resistance; virulence; plasmid; Integrative and Conjugative Element; co-selection; genomics; evolutionpt_PT
dc.subjectGenome evolutionpt_PT
dc.titleAre Virulence and Antibiotic Resistance Genes Linked? A Comprehensive Analysis of Bacterial Chromosomes and Plasmidspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleAntibioticspt_PT
person.familyNameDomingues
person.familyNameRebelo
person.familyNameDionísio
person.familyNameVitorino Nogueira
person.givenNameCélia
person.givenNameJoão
person.givenNameFrancisco
person.givenNameTeresa Isabel
person.identifierA-2129-2009
person.identifierG-2273-2010
person.identifier.ciencia-id3416-6299-1379
person.identifier.ciencia-idA015-FF75-397C
person.identifier.ciencia-id7413-DB46-16E0
person.identifier.ciencia-idF211-4E18-2C69
person.identifier.orcid0000-0003-2970-010X
person.identifier.orcid0000-0002-8662-7378
person.identifier.orcid0000-0002-3653-1511
person.identifier.orcid0000-0002-0059-5177
person.identifier.scopus-author-id6506790127
person.identifier.scopus-author-id7004351448
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication09097aa0-9d09-459f-a089-84f103805fa4
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relation.isAuthorOfPublication.latestForDiscoveryaa2a19c2-e8bf-4b68-98f3-737d4515e13e

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