Publicação
First insights on the susceptibility of native coccidicidal fungi Mucor circinelloides and Mucor lusitanicus to different avian antiparasitic drugs
| dc.contributor.author | Lozano, João | |
| dc.contributor.author | Cunha, Eva | |
| dc.contributor.author | de Carvalho, Luís Madeira | |
| dc.contributor.author | Paz-Silva, Adolfo | |
| dc.contributor.author | Oliveira, Manuela | |
| dc.date.accessioned | 2024-12-20T12:01:53Z | |
| dc.date.available | 2024-12-20T12:01:53Z | |
| dc.date.issued | 2024-02 | |
| dc.description.abstract | Background The combined application of predatory fungi and antiparasitic drugs is a sustainable approach for the integrated control of animal gastrointestinal (GI) parasites. However, literature addressing the possible interference of antiparasitic drugs on the performance of these fungi is still scarce. This research aimed to assess the in vitro susceptibility of six native coccidicidal fungi isolates of the species Mucor circinelloides and one Mucor lusitanicus isolate to several antiparasitic drugs commonly used to treat GI parasites’ infections in birds, namely anthelminthics such as Albendazole, Fenbendazole, Levamisole and Ivermectin, and anticoccidials such as Lasalocid, Amprolium and Toltrazuril (drug concentrations of 0.0078–4 µg/mL), using 96-well microplates filled with RPMI 1640 medium, and also on Sabouraud Agar (SA). Results This research revealed that the exposition of all Mucor isolates to the tested anthelminthic and anticoccidial drug concentrations did not inhibit their growth. Fungal growth was recorded in RPMI medium, after 48 h of drug exposure, as well as on SA medium after exposure to the maximum drug concentration. Conclusions Preliminary findings from this research suggest the potential compatibility of these Mucor isolates with antiparasitic drugs for the integrated control of avian intestinal parasites. However, further in vitro and in vivo studies are needed to confirm this hypothesis. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Lozano, J., Cunha, E., de Carvalho, L.M. et al. First insights on the susceptibility of native coccidicidal fungi Mucor circinelloides and Mucor lusitanicus to different avian antiparasitic drugs. BMC Vet Res 20, 63 (2024). https://doi.org/10.1186/s12917-024-03909-z | pt_PT |
| dc.identifier.doi | 10.1186/s12917-024-03909-z | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.5/96562 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | BMC | pt_PT |
| dc.relation | CIISA/FMV Project UIDB/00276/2020 and LA/P/0059/2020 - AL4AnimalS (both funded by FCT), as well as by Project ED431B 2021/07 (Consellería de Cultura, Educación e Universidades, Xunta de Galicia) | pt_PT |
| dc.relation | PhD Research Fellowship, 2020.09037.BD (funded by FCT). | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.title | First insights on the susceptibility of native coccidicidal fungi Mucor circinelloides and Mucor lusitanicus to different avian antiparasitic drugs | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.title | BMC Veterinary Research | pt_PT |
| oaire.citation.volume | 20 | pt_PT |
| person.familyName | Oliveira | |
| person.givenName | Manuela | |
| person.identifier.ciencia-id | BE1E-2B3B-92D2 | |
| person.identifier.orcid | 0000-0002-3910-1525 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | abd012d1-0b2c-43f6-ba34-5f65c785a479 | |
| relation.isAuthorOfPublication.latestForDiscovery | abd012d1-0b2c-43f6-ba34-5f65c785a479 |