Publicação
First report of occult hepatitis B infection among ART naïve HIV seropositive individuals in Maputo, Mozambique
| dc.contributor.author | Carimo, Awa Abdul | |
| dc.contributor.author | Gudo, Eduardo Samo | |
| dc.contributor.author | Maueia, Cremildo | |
| dc.contributor.author | Mabunda, Nédio | |
| dc.contributor.author | Chambal, Lúcia | |
| dc.contributor.author | Vubil, Adolfo | |
| dc.contributor.author | Flora, Ana | |
| dc.contributor.author | Antunes, Francisco | |
| dc.contributor.author | Bhatt, Nilesh | |
| dc.date.accessioned | 2018-01-11T14:51:51Z | |
| dc.date.available | 2018-01-11T14:51:51Z | |
| dc.date.issued | 2018 | |
| dc.description | © 2018 Carimo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | pt_PT |
| dc.description.abstract | BACKGROUND: The prevalence of hepatitis B virus (HBV) infection and human immunodeficiency virus (HIV) infection in Mozambique is one of the highest in the world, though in spite of this the prevalence of occult hepatitis B infection (OBI) is unknown. OBJECTIVES: This study was conducted with the aim to investigate the prevalence of OBI and frequency of isolated hepatitis B core antibody (anti-HBc alone) among antiretroviral (ART) naïve HIV-positive patients in Mozambique. METHODS: A cross-sectional study was conducted in two health facilities within Maputo city. All ART-naive HIV seropositive patients attending outpatient clinics between June and October 2012 were consecutively enrolled. Blood samples were drawn from each participant and used for serological measurement of HBV surface antigen (HBsAg), antibodies against HBV surface antigen (anti-HBs) and antibodies against core antigen (anti-HBc) using ELISA. Quantification of HBV DNA was performed by real time PCR. A questionnaire was used to obtain demographics and clinical data. RESULTS: Of the 518 ART-naive HIV-positive subjects enrolled in the study, 90.9% (471/518) were HBsAg negative. Among HBsAg negative, 45.2% (213/471) had isolated anti-HBc antibodies, and the frequency of OBI among patients with anti-HBc alone was 8.3% (17/206). OBI was not correlated either with CD4+ T cells count or transaminases levels. A total of 11.8% of patients with OBI presented elevated HBV DNA level. Frequency of individuals with APRI score > 2 and FIB-4 score > 3.25 was higher in patients with OBI as compared not exposed, immune and anti-HBc alone patients. CONCLUSION: Our data demonstrate for the first time that OBI is prevalent among HIV patients in Mozambique, and will be missed using the commonly available serological assays that measures HBsAg. | pt_PT |
| dc.description.sponsorship | This work was supported by Ministry of Health of Mozambique, which participated in study design, data collection and analysis, and the decision to publish and the preparation of the manuscript. The funds were received by NB and ESG. Associação para Investigação e Desenvolvimento da Faculdade de Medicina, Lisbon, Portugal who had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. It was a part of the master thesis in emerging infectious diseases scholarship. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | PLoS ONE 13(1): e0190775. | pt_PT |
| dc.identifier.doi | 10.1371/journal.pone.0190775 | pt_PT |
| dc.identifier.issn | 1932-6203 | |
| dc.identifier.uri | http://hdl.handle.net/10451/30412 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Public Library of Science | pt_PT |
| dc.relation.publisherversion | http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0190775&type=printable | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.title | First report of occult hepatitis B infection among ART naïve HIV seropositive individuals in Maputo, Mozambique | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | e0190775 | pt_PT |
| oaire.citation.title | PLoS ONE | pt_PT |
| oaire.citation.volume | 13 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |