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Proof-of-Concept Study of Multifunctional Hybrid Nanoparticle System Combined with NIR Laser Irradiation for the Treatment of Melanoma

2021Journal article Open access
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dc.contributor.authorLopes, Joana
dc.contributor.authorFerreira-Gonçalves, Tânia
dc.contributor.authorFigueiredo, Isabel V.
dc.contributor.authorRodrigues, Cecília M. P.
dc.contributor.authorFerreira, Hugo
dc.contributor.authorFerreira, David
dc.contributor.authorViana, Ana S.
dc.contributor.authorFaísca, Pedro
dc.contributor.authorGaspar, Maria Manuela
dc.contributor.authorCoelho, João M. P.
dc.contributor.authorSilva, Catarina Oliveira
dc.contributor.authorReis, Catarina Pinto
dc.date.accessioned2025-03-13T17:45:29Z
dc.date.available2025-03-13T17:45:29Z
dc.date.issued2021
dc.description.abstractThe global impact of cancer emphasizes the importance of developing innovative, effective and minimally invasive therapies. In the context of superficial cancers, the development of a multifunctional nanoparticle-based system and its in vitro and in vivo safety and efficacy characterization are, herein, proposed as a proof-of-concept. This multifunctional system consists of gold nanoparticles coated with hyaluronic and oleic acids, and functionalized with epidermal growth factor for greater specificity towards cutaneous melanoma cells. This nanoparticle system is activated by a near-infrared laser. The characterization of this nanoparticle system included several phases, with in vitro assays being firstly performed to assess the safety of gold nanoparticles without laser irradiation. Then, hairless immunocompromised mice were selected for a xenograft model upon inoculation of A375 human melanoma cells. Treatment with near-infrared laser irradiation for five minutes combined with in situ administration of the nanoparticles showed a tumor volume reduction of approximately 80% and, in some cases, led to the formation of several necrotic foci, observed histologically. No significant skin erythema at the irradiation zone was verified, nor other harmful effects on the excised organs. In conclusion, these assays suggest that this system is safe and shows promising results for the treatment of superficial melanoma.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/biom11040511pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/99309
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationFundação para a Ciência e a Tecnologia (FCT) grant number PTDC/BBB-BMC/0611/2012pt_PT
dc.relationFundação para a Ciência e a Tecnologia (FCT) grant number UIDB/00645/2020pt_PT
dc.relationFundação para a Ciência e a Tecnologia (FCT) grant number UIDB/04138/2020pt_PT
dc.relationFundação para a Ciência e a Tecnologia (FCT) grant number UIDP/04138/2020pt_PT
dc.relationFundação para a Ciência e a Tecnologia (FCT) grant number SFRH/BD/148044/2019pt_PT
dc.relationFundação para a Ciência e a Tecnologia (FCT) grant number SFRH/BD/147306/2019pt_PT
dc.subjectmultifunctional nanoparticlespt_PT
dc.subjectgold nanoparticlespt_PT
dc.subjecttargeted therapypt_PT
dc.subjectphotothermal therapypt_PT
dc.subjectsuperficial tumorspt_PT
dc.subjectmelanomapt_PT
dc.subjectexperimental modelspt_PT
dc.titleProof-of-Concept Study of Multifunctional Hybrid Nanoparticle System Combined with NIR Laser Irradiation for the Treatment of Melanomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.startPage511pt_PT
oaire.citation.titleBiomoleculespt_PT
oaire.citation.volume11pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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