Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site

Eberhardy, SR; Goncalves, J; Coelho, S; Segal, DJ; Berkhout, B; Barbas, CF

http://hdl.handle.net/10451/21606

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Abstract(s)

The human immunodeficiency virus type 1 (HIV-1) primer-binding site (PBS) is a highly conserved region in the HIV genome and represents an attractive target for the development of new anti-HIV therapies. In this study, we designed four artificial zinc fin